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CK Life Sciences’ Investigational Cancer Vaccines Deliver Promising Results – New Preclinical Study Data to be Presented at the 2025 American Association for Cancer Research (AACR) Annual Meeting

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HONG KONG SAR – Media OutReach Newswire – 22 April 2025 – CK Life Sciences Int’l., (Holdings) Inc. (“the Company”) announced that the Company will be presenting new data from its cancer vaccine research pipeline at the 2025 American Association for Cancer Research (AACR) Annual Meeting in Chicago, USA.

The AACR Annual Meeting is a gathering central to the global cancer research community, bringing together scientists, clinicians, other healthcare professionals, survivors, patients and advocates every year to share the latest breakthroughs and developments in cancer science and medicine. Last year, the 2024 Annual Meeting attracted 23,000 in-person attendees and 6,700 online participants from 78 countries.

In recent years, CK Life Sciences has regularly participated at the AACR Annual Meeting. The 2025 Annual Meeting will be held from 25-30 April. At the event, CK Life Sciences will exhibit posters highlighting data from preclinical studies of investigational cancer vaccines programs targeting (i) PRAME (Preferentially Expressed Antigen in Melanoma), (ii) PD-L1 (programmed cell death ligand 1), (iii) B7-H3 (B7 homolog 3) and (iv) Claudin 6 proteins, respectively.

PRAME is a protein highly expressed in several cancers, including melanoma, liver cancer and leukemia.

PD-L1 is one of the most important immune checkpoint proteins that is highly expressed in cancer cells to block T cell activation in the tumour microenvironment.

B7-H3 is another immune checkpoint protein that modulates T cell responses and is often overexpressed in cancer.

Claudin 6 is a tight junction protein that regulates epithelial barrier integrity and is overexpressed in cancers like breast cancer, lung cancer and endometrial cancer, where it is associated with tumour progression and metastasis.

In addition, CK Life Sciences will be co-presenting with our research collaborator two posters showcasing our Artificial Intelligence (AI)-empowered platform for designing cancer vaccines.

“CK Life Sciences is pleased with the preclinical efficacy results of its investigational cancer vaccines targeting PRAME, PD-L1, B7-H3 and Claudin 6 proteins, and we hope to further advance the research & development of these and other cancer vaccines. We are also excited about the progress achieved in our efforts to develop an AI platform aimed at designing cancer vaccines that are more likely to be immunogenic and clinically effective,” said Melvin Toh, Vice President and Chief Scientific Officer at CK Life Sciences.

Dr. Toh continued, “CK Life Sciences is determined to accelerate its R&D to benefit cancer patients. Currently, a number of therapeutic cancer vaccines are in clinical and discovery/preclinical research stages. Amongst them, seviprotimut-L, a cancer vaccine already in the final research stage, is being tested for the adjuvant treatment of stage IIB or IIC melanoma following definitive surgical resection.

DETAILS ON POSTER PRESENTATIONS:

  • Abstract 853: PDL1-PRAME dual antigen cancer vaccine inhibits melanoma growth in syngeneic mouse model and induces antigen-specific immune responses

Authors: Kin-Tak Chan, Hsin-Wei Chen, Pi-Hui Liang, You-Yu Lin, Tristan Zhang, Melvin Toh

Session Category: Clinical Research
Session Title: Vaccines and Cell Therapies
Session Date and Time: 4/27/2025 2:00 PM – 5:00 PM
Location: Poster Section 35
Poster Board Number: 9

  • Abstract 3533: Claudin 6 vaccines effectively inhibit tumor growth in a syngeneic mouse colon cancer model

Authors: Na Wang, Melvin Toh, Hong Wang

Session Category: Immunology
Session Title: Vaccines, In Situ Vaccines, and Vaccine Combinations
Session Date and Time: 4/28/2025 2:00 PM – 5:00 PM
Location: Poster Section 39
Poster Board Number: 9

  • Abstract 3536: Synergistic effects of combined PD-L1 and B7-H3 fusion protein vaccination in a mouse model of pancreatic cancer
Authors: Kenneth Nansheng Lin, Melvin Toh, Hong Wang
Session Category: Immunology
Session Title: Vaccines, In Situ Vaccines, and Vaccine Combinations
Session Date and Time: 4/28/2025 2:00 PM – 5:00 PM
Location: Poster Section 39
Poster Board Number: 12

  • Abstract 3538: The development of neoantigen-derived peptide vaccine driven by AI epitope design and computer assisted epitope enhancement

Authors: Chi Han Samson Li, Hong Wang, Kin Tak Chan, Genwei Zhang, Jiewen Du, Lipeng Lai, Melvin Toh

Session Category: Immunology
Session Title: Vaccines, In Situ Vaccines, and Vaccine Combinations
Session Date and Time: 4/28/2025 2:00 PM – 5:00 PM
Location: Poster Section 39
Poster Board Number: 14

  • Abstract 3649: Artificial intelligence accelerates shared neoantigen peptide cancer vaccine development

Authors: Genwei Zhang, Jiewen Du, Xiangrui Gao, Zhenghui Wang, Qingxia Zhang, Tongren Liu, Dong Chen, Chi Han Samson Li, Kin Tak Chan, Hong Wang, Melvin Toh, Lipeng Lai

Session Category: Bioinformatics/ Computational Biology/ Systems Biology/ Convergent Science
Session Title: Artificial Intelligence and Machine Learning for Therapeutic Election and Discovery
Session Date and Time: 4/28/2025 2:00 PM – 5:00 PM
Location: Poster Section 45
Poster Board Number: 11

The full abstracts are available in the AACR Online Itinerary Planner, which can be accessed at: https://www.abstractsonline.com/pp8/#!/20273


DISCLAIMER
This press release may contain forward-looking statements regarding the Group’s research and development projects which may involve risks and uncertainties. Actual results may differ materially from expectations discussed in such forward-looking statements.
All information in this press release is for general reference only and is not intended as investment advice or medical advice. CK Life Sciences Int’l., (Holdings) Inc. does not warrant or represent, express or implied, as to the accuracy, completeness or updated status of such information. No liability will be accepted for any loss or damage howsoever arising from or in reliance upon such information.
Copyright ©2025 CK Life Sciences Int’l., (Holdings) Inc. All rights reserved.

Hashtag: #CKLifeSciences #CancerVaccines #R&D #Pharmaceutical #AmericanAssociationforCancerResearch #AACR #PRAME #PD-L1 #B7-H3 #Claudin6Proteins #Melanoma #AI

The issuer is solely responsible for the content of this announcement.

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Woodfibre LNG Marks 2025 as a Year of Construction Progress, Environmental Stewardship and Community Partnership

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SINGAPORE – Media OutReach Newswire – 24 December 2025 – Woodfibre LNG recently marked 2025 as a year of significant progress across construction, environmental protection and community partnerships, as the project moved deeper into its development phase toward delivering responsibly produced Canadian liquefied natural gas to global markets.

Over the past year, the project advanced from planning into visible, on-the-ground execution. Major construction milestones included the pouring of foundations for key modules, continued progress on marine piling, and further implementation of modular construction techniques designed to reduce on-site footprint while accelerating delivery timelines.

These advancements were achieved through close collaboration with project partners, suppliers and contractors, and in partnership with the Sḵwx̱wú7mesh Úxwumixw (Squamish Nation).

In 2025, Woodfibre LNG, a member of the RGE group of companies founded by Sukanto Tanoto, continued to operate its floatel workforce accommodation solution, designed to minimise pressure on local housing and community services. As of November, two floatels were in active operation, providing high-quality, safe and comfortable living conditions for the project workforce while supporting construction efficiency.

Environmental protection remained a central focus throughout the year. The project’s Marine Mammal Monitoring Programme, which includes hydroacoustic monitoring, exclusion zones and shore-based observation posts, delivered measurable outcomes by enabling real-time operational decisions, including pauses to marine activities when marine mammals entered exclusion areas.

In parallel, remediation of legacy materials from the former pulp mill site continued, with hundreds of thousands of tonnes of historical waste removed. These efforts have contributed to improving site conditions for both local communities and marine and terrestrial ecosystems in Howe Sound.

Woodfibre LNG’s Operator Training Programme, delivered in partnership with the Squamish Nation Training and Trades Centre and the British Columbia Institute of Technology (BCIT), progressed throughout the year. The programme’s first cohort of graduates transitioned into full-time roles, supporting the development of long-term, skilled local employment opportunities linked to the project.

Through its Community Partnership Programme (CPP), Woodfibre LNG continued to invest in local communities across the Sea-to-Sky corridor. In 2025, the programme surpassed $1 million in total grants since its inception, supporting initiatives in sports, healthcare, emergency services, arts and culture, and youth development.

Luke Schauerte, CEO of Woodfibre LNG, said, “2025 has been a year of significant progress for Woodfibre LNG. We are proud of what our team and partners have accomplished together and look forward to building on this momentum in the year ahead.”

With more than half of the project’s development now complete, Woodfibre LNG remains focused on advancing construction safely and responsibly, while maintaining strong partnerships with Indigenous communities, local stakeholders and regulators.

As the project looks ahead to 2026, Woodfibre LNG continues its work toward delivering lower-carbon, responsibly produced Canadian energy to international markets.

Hashtag: #RGE #PacificEnergy #PacificCanbriamEnergy #WoodfibreLNG #LNG #environment #partnerships #LNG #liquefiednaturalgas #energy #sustainability

The issuer is solely responsible for the content of this announcement.

About Woodfibre LNG

The Woodfibre LNG Project is owned by Woodfibre LNG Limited Partnership, owned 70 per cent by Pacific Energy Corporation (Canada) Limited and 30 per cent by Enbridge Inc. The Woodfibre LNG facility is being built on the site of the former Woodfibre pulp mill site, which is located about seven kilometres southwest of Squamish, B.C. Woodfibre LNG will source its natural gas from Pacific Canbriam Energy, a Canadian company with operations in Northeastern British Columbia. Pacific Canbriam is an industry leader in sustainable natural gas production. Woodfibre LNG and Pacific Canbriam Energy are subsidiaries of Pacific Energy Corporation Limited. Woodfibre LNG is the first industrial project in Canada to recognise a non-treaty Indigenous government, Sḵwx̱wú7mesh Úxwumixw (Squamish Nation), as a full environmental regulator.

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New Opportunities in Southeast Asia’s Digital Shift: Thailand Emerges as the New ASEAN’s AI Hub

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BANGKOK, THAILAND – Media OutReach Newswire – 24 December 2025 – As global attention remains fixed on the AI race, Thailand is now carving out a new identity as an emerging “AI Hub for Association of Southeast Asian Nations (ASEAN).” The government is steadily advancing its “Thailand 4.0” initiative, positioning the digital economy as the key driver of national transformation.

The expansion of AI and data centers (DCs) in Thailand is driving several transformative trends:

  • Changing data traffic patterns. As DCs multiply in Bangkok, Chonburi, and beyond, Thailand is evolving from a traditional data “transit point” into a regional “convergence hub.” East-west digital traffic is accelerating, with Thai DC clusters increasingly meeting the computing demands of Southeast Asia and the broader Asia-Pacific.
  • Optimized data routing. Data flows that once relied on submarine cables via Hong Kong and Singapore are gradually shifting to land-based digital corridors linking China, Laos, and Thailand. This route reduces data transmission latency from southwestern China to Southeast Asia.
  • Elevated business expectations. Demand is shifting beyond “sufficient bandwidth” toward “high-quality experience.” Thailand sits in a “latency sweet spot” for key Asia-Pacific markets, with latencies to Singapore, Vietnam, and Malaysia falling within an optimal range—a crucial advantage for latency-sensitive sectors like autonomous driving, telemedicine, and fintech.

New opportunities inevitably bring new challenges, and Thailand also addresses the following three challenges:

1. Massive traffic impacting existing networks: Compared with mature hubs like Singapore, Thailand has insufficient international submarine cables. A large volume of cross-border data still needs to be transmitted through detours. Meanwhile, as DC investments continue to accelerate, traffic will keep rising. Analysis shows that by 2029, Thailand’s DC capacity may reach 2000 MW, with cross-region traffic surging to 630 Tbps. The current network architecture is no longer capable of supporting such heavy traffic.

2. Latency advantages not fully realized: Despite its geographic advantages, Thailand’s network latency performance has yet to reach its full potential. Routes to key markets, like China, still require third-party transit. What’s more, traditional network scheduling lacks intelligent route selection capabilities, making it difficult to provide deterministic assurance for latency-sensitive services like financial transactions and real-time AI interactions.

3. Potential risks in network reliability: Thailand’s network reliability faces structural challenges. Single points of failure have previously caused hours-long interruptions to critical services, directly undermining enterprise users’ confidence.

To overcome these challenges, Thailand can take a systematic approach to upgrading its digital infrastructure, aiming to build next-generation AI-ready networks.

1. Building ultra-high-bandwidth “sea-land” connectivity. By actively introducing new submarine cables, Thailand can significantly enhance its connectivity with the Asia-Pacific region and the world. Meanwhile, accelerating the construction and expansion of key terrestrial cable routes—such as China-Laos-Thailand and Thailand-Malaysia-Singapore—will transform Thailand’s geographic advantage into a tangible connectivity advantage.

2. Optimizing network routes to create a regional low-latency core. Strengthening the Kunming-Laos-Thailand terrestrial cable route will continuously reduce transmission latency between China and Thailand, meeting the needs of real-time applications. In addition, the introduction of autonomous networks will enable automatic selection of the optimal, shortest route, shifting from “best effort” to “deterministic low latency.”

3. Designing a “never-interrupted” high-resilience architecture. Deploying active-active DC networks with millisecond-level switchover capabilities ensures the continuity of core services. Meanwhile, AI-driven intelligent O&M can reduce fault detection and diagnosis from hours to minutes.

Thailand’s booming AI and DC industries are driving rapid growth in regional and cross-border business demand. In this trend, network infrastructure construction centered on DCs is the core engine that drives AI transformation, propelling Thailand toward its vision of becoming the new AI hub for ASEAN.

Hashtag: #huawei

The issuer is solely responsible for the content of this announcement.

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MyRepublic Launches Card Sub, Singapore’s First Subscription Service for Trading Card Game Fans

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SINGAPORE – Media OutReach Newswire – 23 December 2025 MyRepublic today announced the launch of Card Sub, a new subscription-based service designed for Trading Card Game (TCG) enthusiasts. Card Sub offers subscribers a convenient way to receive Magic: The Gathering (MTG) products monthly, including access to premium booster packs not typically available through standard retail purchases.

MyRepublic Launches Card Sub, Singapore’s First Subscription Service for Trading Card Game Fans

Card Sub introduces a structured monthly subscription model in which customers pay a fixed monthly rate and receive up to 3 Play Booster packs or 2 Play booster boxes from the current MTG release. In addition, subscribers will receive free premium booster packs or boxes. These premium boosters may include Collector Booster Packs or Boxes, such as the highly sought-after Final Fantasy Collector Booster, which is constantly sold out worldwide which features the extremely valuable serialised Golden Chocobo card
“The trading card community in Singapore is incredibly passionate, and Card Sub is our small way of adding value to that ecosystem,” said Terry Williams, Head of Consumer at MyRepublic. “As TCG players ourselves, we wanted to offer something to the community to provide an easier access to the latest release every month, and the chance to secure premium packs that might not be readily accessible to players. We see Card Sub as a community-driven initiative, open to all who share a passion for growing the hobby.”
The subscription tiers available at launch are:
MyRepublic Card Sub Plans
MyRepublic Card Sub Plans

Card Sub will be available to both MyRepublic and non-MyRepublic customers. All product redemptions will take place in person at the upcoming Card Arena by MyRepublic, located at Suntec City. Customers will redeem their Premium booster or box in-store.

Card Sub is positioned to serve cost-conscious TCG consumers by providing reliable monthly access to boosters with the added benefit of premium packs or boxes at no additional charge. The inclusion of Collector Boosters in the premium pool provides an opportunity for subscribers to obtain higher-value products through a predictable monthly model. MyRepublic also plans to expand Card Sub to additional TCG franchises, including Pokémon.
Card Sub is open for sign-up at cardsub.net and available to everyone in Singapore. Monthly redemption of subscription items will be fulfilled exclusively at:
Card Arena by MyRepublic
Suntec City, 3 Temasek Boulevard, #02-323/324

Hashtag: #CardSub, #MyRepublic #MyRepublicCardSub #CardSubSG #TCG #GeeksUseUs





The issuer is solely responsible for the content of this announcement.

MyRepublic

MyRepublic is an award-winning telecom operator whose values lie in the future of connectivity, the next opportunity to disrupt, and innovations that will make a real difference. The provider’s priority is to redefine broadband and mobile connectivity in the markets it operates and empower customers to understand what a true modern connectivity experience can be.
For more information, please visit
cardsub.net

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