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CK Life Sciences’ Investigational Cancer Vaccines Deliver Promising Results – New Preclinical Study Data to be Presented at the 2025 American Association for Cancer Research (AACR) Annual Meeting

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HONG KONG SAR – Media OutReach Newswire – 22 April 2025 – CK Life Sciences Int’l., (Holdings) Inc. (“the Company”) announced that the Company will be presenting new data from its cancer vaccine research pipeline at the 2025 American Association for Cancer Research (AACR) Annual Meeting in Chicago, USA.

The AACR Annual Meeting is a gathering central to the global cancer research community, bringing together scientists, clinicians, other healthcare professionals, survivors, patients and advocates every year to share the latest breakthroughs and developments in cancer science and medicine. Last year, the 2024 Annual Meeting attracted 23,000 in-person attendees and 6,700 online participants from 78 countries.

In recent years, CK Life Sciences has regularly participated at the AACR Annual Meeting. The 2025 Annual Meeting will be held from 25-30 April. At the event, CK Life Sciences will exhibit posters highlighting data from preclinical studies of investigational cancer vaccines programs targeting (i) PRAME (Preferentially Expressed Antigen in Melanoma), (ii) PD-L1 (programmed cell death ligand 1), (iii) B7-H3 (B7 homolog 3) and (iv) Claudin 6 proteins, respectively.

PRAME is a protein highly expressed in several cancers, including melanoma, liver cancer and leukemia.

PD-L1 is one of the most important immune checkpoint proteins that is highly expressed in cancer cells to block T cell activation in the tumour microenvironment.

B7-H3 is another immune checkpoint protein that modulates T cell responses and is often overexpressed in cancer.

Claudin 6 is a tight junction protein that regulates epithelial barrier integrity and is overexpressed in cancers like breast cancer, lung cancer and endometrial cancer, where it is associated with tumour progression and metastasis.

In addition, CK Life Sciences will be co-presenting with our research collaborator two posters showcasing our Artificial Intelligence (AI)-empowered platform for designing cancer vaccines.

“CK Life Sciences is pleased with the preclinical efficacy results of its investigational cancer vaccines targeting PRAME, PD-L1, B7-H3 and Claudin 6 proteins, and we hope to further advance the research & development of these and other cancer vaccines. We are also excited about the progress achieved in our efforts to develop an AI platform aimed at designing cancer vaccines that are more likely to be immunogenic and clinically effective,” said Melvin Toh, Vice President and Chief Scientific Officer at CK Life Sciences.

Dr. Toh continued, “CK Life Sciences is determined to accelerate its R&D to benefit cancer patients. Currently, a number of therapeutic cancer vaccines are in clinical and discovery/preclinical research stages. Amongst them, seviprotimut-L, a cancer vaccine already in the final research stage, is being tested for the adjuvant treatment of stage IIB or IIC melanoma following definitive surgical resection.

DETAILS ON POSTER PRESENTATIONS:

  • Abstract 853: PDL1-PRAME dual antigen cancer vaccine inhibits melanoma growth in syngeneic mouse model and induces antigen-specific immune responses

Authors: Kin-Tak Chan, Hsin-Wei Chen, Pi-Hui Liang, You-Yu Lin, Tristan Zhang, Melvin Toh

Session Category: Clinical Research
Session Title: Vaccines and Cell Therapies
Session Date and Time: 4/27/2025 2:00 PM – 5:00 PM
Location: Poster Section 35
Poster Board Number: 9

  • Abstract 3533: Claudin 6 vaccines effectively inhibit tumor growth in a syngeneic mouse colon cancer model

Authors: Na Wang, Melvin Toh, Hong Wang

Session Category: Immunology
Session Title: Vaccines, In Situ Vaccines, and Vaccine Combinations
Session Date and Time: 4/28/2025 2:00 PM – 5:00 PM
Location: Poster Section 39
Poster Board Number: 9

  • Abstract 3536: Synergistic effects of combined PD-L1 and B7-H3 fusion protein vaccination in a mouse model of pancreatic cancer
Authors: Kenneth Nansheng Lin, Melvin Toh, Hong Wang
Session Category: Immunology
Session Title: Vaccines, In Situ Vaccines, and Vaccine Combinations
Session Date and Time: 4/28/2025 2:00 PM – 5:00 PM
Location: Poster Section 39
Poster Board Number: 12

  • Abstract 3538: The development of neoantigen-derived peptide vaccine driven by AI epitope design and computer assisted epitope enhancement

Authors: Chi Han Samson Li, Hong Wang, Kin Tak Chan, Genwei Zhang, Jiewen Du, Lipeng Lai, Melvin Toh

Session Category: Immunology
Session Title: Vaccines, In Situ Vaccines, and Vaccine Combinations
Session Date and Time: 4/28/2025 2:00 PM – 5:00 PM
Location: Poster Section 39
Poster Board Number: 14

  • Abstract 3649: Artificial intelligence accelerates shared neoantigen peptide cancer vaccine development

Authors: Genwei Zhang, Jiewen Du, Xiangrui Gao, Zhenghui Wang, Qingxia Zhang, Tongren Liu, Dong Chen, Chi Han Samson Li, Kin Tak Chan, Hong Wang, Melvin Toh, Lipeng Lai

Session Category: Bioinformatics/ Computational Biology/ Systems Biology/ Convergent Science
Session Title: Artificial Intelligence and Machine Learning for Therapeutic Election and Discovery
Session Date and Time: 4/28/2025 2:00 PM – 5:00 PM
Location: Poster Section 45
Poster Board Number: 11

The full abstracts are available in the AACR Online Itinerary Planner, which can be accessed at: https://www.abstractsonline.com/pp8/#!/20273


DISCLAIMER
This press release may contain forward-looking statements regarding the Group’s research and development projects which may involve risks and uncertainties. Actual results may differ materially from expectations discussed in such forward-looking statements.
All information in this press release is for general reference only and is not intended as investment advice or medical advice. CK Life Sciences Int’l., (Holdings) Inc. does not warrant or represent, express or implied, as to the accuracy, completeness or updated status of such information. No liability will be accepted for any loss or damage howsoever arising from or in reliance upon such information.
Copyright ©2025 CK Life Sciences Int’l., (Holdings) Inc. All rights reserved.

Hashtag: #CKLifeSciences #CancerVaccines #R&D #Pharmaceutical #AmericanAssociationforCancerResearch #AACR #PRAME #PD-L1 #B7-H3 #Claudin6Proteins #Melanoma #AI

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TruCare Dental Invites Community to ‘Complimentary Orthodontic Consultation Days

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HONG KONG SAR – Media OutReach Newswire – 16 May 2025 – TruCare Dental is inviting the public to take the first step toward a healthier and more confident smile by attending its upcoming Complimentary Orthodontic Consultation Days. The event will be held on May 24 and June 28, 2025, from 10:00 AM to 2:00 PM at the clinic’s conveniently located Tsim Sha Tsui practice.

Transforming Smiles Through Expert Guidance

Orthodontic Consultation Days are tailored for anyone considering braces or aligners but uncertain about their options. Attendees will benefit from the expertise of TruCare Dental’s highly qualified team—all graduates of the University of Hong Kong’s Bachelor of Dental Surgery program—who will provide personalized, one-on-one orthodontic assessments and clear recommendations.

What Participants Can Expect

Guests who register for the event will receive:

  • Comprehensive oral evaluation: A detailed examination by a registered dentist to assess individual needs
  • Bite and alignment analysis: Professional insights into current dental alignment and potential improvements
  • Preliminary diagnosis and treatment planning: Customized guidance on possible orthodontic solutions
  • Overview of braces and aligner options: Information on both traditional metal braces and modern invisible aligners
  • Transparent discussion of pros, cons, and timelines: Clear explanations regarding each treatment’s suitability, advantages, and expected duration
  • Cost breakdown and installment options: Detailed cost estimates and available payment plans for affordable care
In addition, the TruCare Dental team will dispel common myths—such as the misconception that orthodontic treatment is only for children or that it damages teeth—enabling participants to make confident, informed decisions.

TruCare Dental is dedicated to delivering exceptional dental care with a strong emphasis on patient education and individualized treatment. The clinic’s mission is to help every patient achieve optimal oral health and a confident smile through compassionate, professional service.

Registration Details

Due to the personalized nature of the consultations, advance registration is required and spaces are limited. Interested individuals are encouraged to secure an appointment as soon as possible by calling 2152 0280 or by visiting the online registration page.

Event Venue:
Room 2201, 22/F, Tower A, Mira Place, Tsim Sha Tsui
Hashtag: #TruCareDental

The issuer is solely responsible for the content of this announcement.

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LEGOLAND® Malaysia Resort Launches Asia’s Biggest LEGO® School Challenge 2025

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Grand Prize Trip to Korea, New Speed Building Finale, and Unforgettable Prizes Await Young Builders!

JOHOR BAHRU, MALAYSIA – Media OutReach Newswire – 16 May 2025 – Ready, set, build! The most anticipated LEGO® school event in Asia is back—and it’s bigger, bolder, and more inspiring than ever. The LEGOLAND® Malaysia School Challenge 2025, organized in partnership with the Ministry of Education, kicks off its fourth edition with a mission to unlock the boundless creativity of students across the region.

(From left to right) Ms Stephane Thong, General Manager, Trip.com Malaysia, Ms Thila Munusamy, Director of Sales and Marketing, LEGOLAND Malaysia Resort, Mr Samuel Lee, Deputy Director General of the Malaysian Tourism Promotion Board, Mr Mohamad Zaidi Bin Ishak, Deputy Director of Sports, Co-Curricular and Arts Department, Ministry of Education Malaysia and Mr Cs Lim, Vice President, LEGOLAND Malaysia Resort

Since its inception in 2022, the Challenge has become a regional phenomenon. Following record-breaking participation in 2024, this year promises an even more thrilling experience, packed with new features and prizes that spark imagination and ignite a passion for learning.

New Theme, New Thrills: “Build Your Dream Destination”
Now open to three age categories (7–9, 10–12, and 13–17), the 2025 edition challenges students to design their ideal travel destination using LEGO bricks. Whether it’s a futuristic underwater world, an island of imagination, or a dreamland among the stars, participants are encouraged to combine creativity, storytelling, and technical building skills to bring magical destinations to life.

What’s New in 2025?
Two major updates make this year’s Challenge truly unmissable:

  • Grand Prizes Go Global: Winners from the Primary and Secondary Categories will experience a trip to LEGOLAND Korea, while Junior Category champions will enjoy a getaway at LEGOLAND Malaysia.
  • Speed Building Showdown: For the first time, the finale will feature a high-energy Speed Building Challenge. The Top 5 finalist teams in each category will compete live in front of a judging panel and audience, racing against the clock to create an original LEGO build in just 45 minutes.

Each finalist team will also enjoy a 3D2N stay at LEGOLAND Hotel, receive exclusive LEGO trophies, exciting LEGO sets, and Annual Passes to LEGOLAND Malaysia Resort.

Inspiring Young Innovators: A Story of Growth
Among the Challenge’s most inspiring alumni is Nathanael Yap, a three-time Grand Prize winner. At the launch event, he shared:

“Being part of the LEGOLAND School Challenge for three years in a row was honestly one of the best parts of my school life. Every year, I got to team up with friends, solve problems in creative ways, and build something we were proud of — brick by brick. It taught me how fun learning can be when you get to think outside the box.

Even though I’ve graduated and can’t take part anymore, the experience has stayed with me. As I look ahead to university and start thinking more seriously about my future, I realise how much the Challenge helped shape my interests — especially in areas like design, engineering, and creative thinking. I’m excited to see what this year’s participants will build, and I hope they take the chance to push themselves and discover what they’re capable of.”

His story reflects what the Challenge is all about – empowering young minds to explore, imagine, and create.

Shaping Future Creators, One Brick at a Time
Cs Lim, Vice President of LEGOLAND Malaysia Resort, remarked, “The LEGOLAND School Challenge has always been more than just a competition. As an event centered around our LEGO DNA of learning through play, it helps cultivate essential skills such as problem solving, critical thinking, and innovation in our future leaders. Since we expanded last year to include participation from schools across Asia, this has also become an avenue for cultural exchange for students and teachers alike. We look forward to welcoming more participants this year across the region and seeing their creativity unleashed.”

The 2025 Challenge is proudly supported by the Ministry of Education, Tourism Malaysia, Trip.com Group, and the LEGO Group—all sharing a common goal: to ignite the passions of the next generation of builders, dreamers, and doers.

Register for the LEGOLAND School Challenge 2025
The competition is open to students aged 7 to 17 across three separate categories:

  • Junior: Ages 7 to 9
  • Primary: Ages 10 to 12
  • Secondary: Ages 13 to 17

Each team must consist of 3-4 students and 1 teacher. Registration is open from now until 15 June 2025 via https://www.legoland.com.my/tickets-passes/day-tickets/schools/school-challenge/. Follow us for updates, tips and behind-the-scenes on Facebook and Instagram.

Let your imagination run wild. Build your dream destination—and win the trip of a lifetime!

Hashtag: #LEGOLAND® #LEGO®




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LEGOLAND® Malaysia Resort

LEGOLAND® Malaysia Resort brings together a LEGOLAND Theme Park, Water Park, Hotel and SEA LIFE in one LEGO® themed location. It is the ideal family holiday destination with more than 80 hands-on rides, slides, shows, and attractions. It is the first of its kind in Asia that offers comprehensive adventure, education, and fun for either an action-packed day trip or a short break destination ideal for families with kids aged 2 to 12 years old.

The Theme Park is divided into eight themed areas containing thrilling rides, exciting LEGO workshops, awe-inspiring Miniland where Asia’s interesting landscapes, countries and landmarks are recreated in miniature made with more than 30 million LEGO bricks. The Water Park is the largest LEGOLAND Water Park in Asia which features 20 unique slides, waves, wade pools, interactive water-play structure and Build-A-Raft River.

LEGOLAND Hotel Malaysia is the first LEGO themed hotel in Asia. Choose your preferred theme room at a hotel all equipped with LEGO theming elements, giving you choices to be trained like a NINJA, playing pirate, commanding a Kingdom or embarking on an adventure option. All rooms include a king-sized bed for parents and a separate private sleeping area for 3 kids. Participate in our in-room treasure hunt activity and stand a chance to win cool LEGO gifts.

SEA LIFE is the world’s largest international aquarium brand with more than 50 outlets in the world and it is the latest addition to LEGOLAND Malaysia Resort. This attraction will immerse all guests in an intimate and interactive journey underneath the waves. All guests will have a chance to enjoy up-close experiences with sea creatures and be inspired to learn more about our blue planet’s invaluable natural marine assets through magical storytelling, interactive displays and hands-on encounters. SEA LIFE Malaysia has more than 25 display tanks in 11 habitat zones featuring 13,000 amazing sea creatures. The Malaysian Rainforest is one of the unique exhibit zones featuring local creatures in Malaysia. Don’t miss this special zone where you can never find it in other SEA LIFE attractions.

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Transform Your Home with the Next-Generation Cleaning Companion: Tineco’s Young Series – Powerful, Efficient, and Affordable

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  • Tineco launches the Young Series with three new floor washers: the Y2, Y3, and Y5 Stretch Ultra
  • Experience the ultimate cleaning experience with these innovative floor washers, where cutting-edge technology meets energy efficiency and sleek design for unmatched performance

SINGAPORE – Media OutReach Newswire – 16 May 2025 – Tineco, a global leader in smart cleaning technology, today announced the official launch of its Young Series Floor Washers in Singapore. Designed with new homeowners and first-time users in mind, the series features three value-driven models—Y2, Y3, and Y5 Stretch Ultra—offering high-performance cleaning at an accessible price point of just $299 onwards.

Tineco Young Series

YOUNG SERIES: PERFECT FOR THE SINGAPORE HOUSEHOLDS WITH ITS COMPACT BUILD AND EFFICIENT TECHNOLOGIES

The Young Series delivers professional grade cleaning, making it ideal for everyday messes. Designed to handle wet and dry debris, pet hair, and edge dust with ease, these versatile floor washers work seamlessly across hard floors and carpets. All models feature a convenient one-touch self-cleaning. Experience premium cleaning at an accessible price—Tineco’s Young Series delivers top-tier value.

From left to right: Y5 Stretch Ultra, Y3, and Y2
From left to right: Y5 Stretch Ultra, Y3, and Y2

Meanwhile, the Y3 and Y5 Ultra models gives you an elevated cleaning experience that includes:

  • 5-Minute Hot Air Drying and 85°C Hot Water Self-Cleaning: Keeping your vacuum clean with this cutting-edge system that eliminates odors and bacterial growth.
  • 180° Lay Flat Design (Y5 Stretch Ultra): With its 13cm ultra slim profile, it can reach places that are harder than usual to access, guaranteeing a 360° deep clean.

In conjunction with the launch, from May 19th to June 8th, all Courts stores and Courts.com.sg will offer a range of exclusive promotions. It is the perfect opportunity for new and young families to upgrade their cleaning routine and enjoy a superior, fuss-free cleaning experience.

AVAILABILITY & LAUNCH PROMOTIONS

Device Availability Launch Promotions

T&Cs apply, while stocks last

Y2 (Entry-Level)

$299 (u.p $499)

Available now at Courts, Shopee, and Lazada Exclusively at Courts, from May 19th to June 8th

Free Tineco Woven bag (worth $49 or wagon (worth $299).

Y3 (Hot Drying)

$399 (u.p $799)

Available now on Courts ,Shopee, and Lazada
Y5 Stretch Ultra

$549 (u.p $999)

Available now on Courts, Shopee, Lazada

Hashtag: #Tineco

The issuer is solely responsible for the content of this announcement.

Tineco

Founded in 1998, Tineco is a high-tech company and a wholly-owned subsidiary of ECOVACS Group (SHA: 603486). Dedicated to innovation, Tineco has consistently delivered smart home cleaning solutions that redefine convenience and efficiency. Tineco has secured “World No.1” sales in the wet & dry category in 2024. With the launch of the Young series, Tineco continues to lead the way in creating products that make everyday life easier and more enjoyable.

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