Media OutReach
Triple agonist UBT251 delivers up to 19.7% mean weight loss after 24 weeks in phase 2 trial in China
- UBT251 is a triple agonist of the receptors for GLP-1, GIP and glucagon (triple G), being jointly developed by United Biotechnology and Novo Nordisk
- In a placebo-controlled phase 2 trial in Chinese people with overweight or obesity, UBT251 led to a statistically significant mean weight loss of up to 19.7% after 24 weeks
- UBT251 appeared to have a safe and well-tolerated profile consistent with incretin-based therapies.
GUANGDONG, CHINA & BAGSVÆRD, DENMARK – Media OutReach Newswire – 24 February 2026 – The United Laboratories International Holdings Limited (TUL) and Novo Nordisk A/S (Novo Nordisk) today announced topline results from a Chinese phase 2 trial of UBT251, a triple agonist of the receptors for GLP-1, GIP, and glucagon (triple G).
UBT251 is being jointly developed by TUL’s wholly-owned subsidiary The United Bio-Technology (Hengqin) Co., Ltd. (United Biotechnology) and Novo Nordisk under an agreement signed in March 2025. United Biotechnology is responsible for development in Chinese mainland, Hong Kong, Macau and Taiwan, while Novo Nordisk is responsible for development in the rest of the world.
The trial, conducted by United Biotechnology, investigated the safety and efficacy of once-weekly injectable 2 mg, 4 mg and 6 mg doses of UBT251 compared to placebo in Chinese people with overweight or obesity. From a baseline mean body weight of 92.2 kg, the highest mean weight loss observed for people treated with UBT251 was 19.7% (-17.5 kg) compared to 2.0% (-1.6kg) in the placebo group after 24 weeks of treatment[i].
Moreover, all dose groups of UBT251 showed statistically significant improvements relative to placebo on key secondary endpoints, including waist circumference, blood glucose, blood pressure and lipids.
In the trial, UBT251 appeared to have a safe and well-tolerated profile. The most common adverse events were gastrointestinal, and the vast majority were mild to moderate and diminished over time, consistent with incretin-based therapies.
“The success of the phase 2 clinical trial of UBT251 in China represents another significant milestone in TUL’s innovation-driven development,” said Mr Tsoi Hoi Shan, Chairman of TUL. “We will continue to focus on chronic diseases, including endocrine and metabolic disorders, accelerate the further development of UBT251, and strive to bring more high-quality treatment options to patients worldwide at the earliest opportunity.”
“We are very encouraged by these data from the trial in China, which demonstrate the potential of UBT251 and its differentiated clinical profile and safety and tolerability profile,” said Martin Holst Lange, executive vice president, chief scientific officer and head of Research and Development at Novo Nordisk. “We look forward to reporting data from a global trial with UBT251 conducted by Novo Nordisk next year.”
Novo Nordisk recently initiated a global phase 1b/2a trial investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of different doses of UBT251 for up to 28 weeks in around 330 people living with overweight or obesity. Topline data from that trial is expected in 2027. Novo Nordisk also expects to initiate a phase 2 trial with UBT251 in people with type 2 diabetes in the second half of 2026.
United Biotechnology will present detailed data from the Chinese phase 2 trial at a medical congress later this year. Based on the results of this trial, the company is planning to initiate a phase 3 trial in Chinese patients with overweight or obesity.
About the Chinese phase 2 trial
This randomized, double-blind, placebo-controlled trial enrolled a total of 205 Chinese patients with obesity (BMI ≥ 28.0 kg/m²) or overweight (24.0 kg/m² ≤ BMI < 28.0 kg/m²) with at least one weight-related comorbidity. The baseline mean body weight of the patients was 92.2 kg, with a baseline mean BMI of 33.1 kg/m².
Patients were randomly assigned to receive weekly subcutaneous injections of UBT251 in doses of 2 mg, 4 mg, 6 mg, or placebo for 24 weeks.
The primary endpoint of the trial was the percentage change in body weight from baseline after 24 weeks of treatment.
About UBT251
UBT251 is a long-acting synthetic peptide triple agonist targeting the receptors for GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide) and glucagon.
In March 2025, United Biotechnology entered an exclusive license agreement with Novo Nordisk A/S for UBT251. Under the agreement, Novo Nordisk obtained exclusive worldwide rights (excluding Chinese mainland, Hong Kong, Macau, and Taiwan) to develop, manufacture and commercialise UBT251. United Biotechnology retained the rights for UBT251 in Chinese mainland, Hong Kong, Macau and Taiwan.
Hashtag: #UBT251
The issuer is solely responsible for the content of this announcement.
About TUL and United Biotechnology
Founded in 1990, TUL (HKEX: 3933) is mainly engaged in the research and development, production and sales of pharmaceuticals, and ranks among the leading integrated pharmaceutical companies in China. TUL currently boasts seven production bases, covering intermediate products, bulk medicine, finished products, veterinary drugs, empty capsule casings, and medical devices, with the sales networks dotted across nearly 80 countries and regions. United Biotechnology, located in the Guangdong-Macao In-Depth Cooperation Zone in Hengqin, serves as the biopharmaceutical R&D headquarter of TUL. United Biotechnology focuses on the development of high-end biopharmaceuticals to treat major chronic diseases. For more information, please visit www.tul.com.cn.
About Novo Nordisk
Novo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat serious chronic diseases, built upon our heritage in diabetes. We do so by pioneering scientific breakthroughs, expanding access to our medicines, and working to prevent and ultimately cure disease. Novo Nordisk employs about 68,800 people in 80 countries and markets its products in around 170 countries. For more information, visit novonordisk.com, YouTube.
Media OutReach
A Pandastic Summer Birthday Celebration at Ocean Park Chance to win the all-new MAXUS MIFA 7 PLUS Pure Electric 7-Seater MPV
Even more exciting, visitors could take home fabulous prices, including the newly launched MAXUS MIFA 7 PLUS, the mid-size family pure electric MPV – by entering the Summer Joy Lucky Draw* on every eligible visit during the promotion period of 3 July and 31 August 2026!
Birthday photo spots and Panda Friends encounters
Celebrate the pandas’ special days with pandastic photo opportunities across the Park. Capture snapshots at the main entrance’s gigantic birthday countdown zone. Don’t miss the charming 5-metre-tall Giant Panda Birthday Bun Tower at Waterfront Plaza, adorned with piles of pink birthday buns to celebrate the pandas’ birthdays in true Hong Kong style.
Explore the Panda Friends Cute & Cuddly zone at Eco-Herbal Trail, featuring over 60 Panda Friends sculptures, each carrying magnifying sunglasses and cameras, ready to discover the wonders of nature.
The precious panda moments
Relive the heartwarming journey of all six giant pandas at the Pandastic Happy Moments exhibit next to the Hong Kong Jockey Club Sichuan Treasures. This special display showcases precious footage commemorating the rapid growth of twins Jia Jia and De De and other adorable life stages from all the giant panda members. It is a truly unmissable experience for all panda enthusiasts.
Fans can also visit the Giant Panda Fans Zone near the exhibit, created for fans to meet and connect and exchange their own handmade crafts and treasured panda keepsakes until 31 August 2026!
Summer splashing fun with Panda Friends
Dive into body-cooling water fun at the Panda Friends Splashy Birthday Camp outside Applause Pavilion. Experience the thrill of dashing through giant water curtains or facing a massive waterfall-style deluge from the mega water bucket. Unleash your playful instincts with all-time favourite water bomb fights at Panda Friends Water Bomb Fun or get caught in refreshing water gun ambushes from Ocean Park’s special Celebration Squad during their energetic Pandastic Birthday Splash, featuring adorable dance routines inspired by the panda twins.
Delightful entertainment and limited-edition performances
The highly-anticipated Pandastic Summer Birthday Spectacular features giant inflatable Panda Friends roaming the Park, accompanied by various performance groups delivering vibrant songs and dances at the Pawsome Summer Party on 8, 15 and 16 August 2026. Ocean 6N1 dress up with their special birthday outfits and showcase incredible singing and dancing in All Star Jam talent show. Whiskers & Friends will also give a birthday edition special performance at Ocean Park Star Match. Ocean Park’s lively roving band will also keep the festive atmosphere high.
Exclusive collectibles
Commemorate the twins’ second birthday with exclusive, limited-edition Giant Panda Birthday stamps. Collect all the stamps from designated Park locations to complete your very own beautiful birthday card. Test your skills and reflexes at interactive game booths to win special prizes. The talented coloured-chalk artists painting adorable giant panda figures in the Park.
Adorable merchandise and food and beverage
Check out our adorable Panda Friends Summer Collection, vibrant with colourful and summery designs. Highlights include the Giant Panda Plush Keychain Blind Box, featuring all the Panda Friends in their cutest summer outfits. Jia Jia and De De have transformed into the “Lemon Twins”, starring in a new range of summer essentials to keep everyone cool and refreshed throughout the season. Equally unmissable is the Panda Friends Hong Kong Food Collection, which charmingly captures iconic Hong Kong food elements.
Beyond these, the all-new Ocean Park x Maltese Crossover Series and the Panda Friends Hong Kong Food Collection prize items will be making their way to game booths across the Park, starting from mid-July. On top of that, fans can also look forward to Panda Friends photo frame, claw machines and press penny machines to bring in another level of excitement.
To celebrate the giant pandas’ birthdays, Ocean Park has prepared a tempting lineup of panda-themed treats, including the Panda Twins Mini Burgers and Panda Snack Platter. No birthday celebration is complete without desserts and cakes. The Park has also launched a delightful selection of treats, as well as refreshing snow cones and frozen fruits for visitors to beat the summer heat. What’s more, other restaurants across the Park will be introducing a summer menu featuring fruit-inspired recipes, so you can savour the flavours of summer with surprises in every bite.
Summer Joy Lucky Draw
Adding a final layer of excitement, the Summer Joy Lucky Draw* offers fantastic surprises. From 3 July to 31 August 2026, upon Park admission, visitors can register to participate for a chance to win from over 1,000 prizes with a total value of more than HK$815,000, including the grand prize, a brand-new MAXUS MIFA 7 PLUS Pure Electric 7-Seater MPV worth HK$369,102, sponsored by Inchcape Hong Kong. Every visit offers another chance to win!
Pair up and dive into summer fun with Summer Duo Pass
Pair up with a friend or family for an unforgettable summer adventure and enjoy up to 30% off with the Summer Duo Pass# available from now until 31 August 2026. Weekday tickets for two adults or two kids start at HK$753 and HK$377 respectively, while any-day tickets for two adults or two kids start at HK$861 and HK$430 respectively.
New Get Closer to the Animals experiences
Beyond the panda birthday festivities, Ocean Park is launching two new Get Closer to the Animals programmes. You can enjoy snorkelling in the Park’s world-class aquarium and visit behind the scenes to interact with the mysterious yet adorable sharks and rays for the very first time in the newly launched Fish Friends Face-Off X Shark & Ray Discovery! There is also a new Meerkat Feeding experience for visitors to learn more about these adorable ambassadors!
Elevating the digital visitor experience
To coincide with the launch of Ocean Park’s summer celebrations, Ocean Park is also enhancing its digital experience with a redesigned official website, which features enhanced mobile compatibility and a more intuitive browsing experience across all devices. This new website supersedes the previous mobile application and enables viewers to access the latest park information anytime, anywhere on one platform.
Ocean Park Named “Muslim-friendly Attraction of The Year”
Ocean Park has been named Muslim-friendly Attraction of The Year at the prestigious Halal in Travel Awards 2026 organised by CrescentRating, the world’s leading consultant on Muslim-friendly tourism. This recognition highlights the Park’s dedication to welcoming diverse guests through comprehensive facilities, including dedicated prayer rooms and an expanded portfolio of Halal-certified dining options like the recently certified Bayview Restaurant. With this milestone, Ocean Park looks forward to welcoming even more international visitors to experience its unique blend of conservation, entertainment, and exceptional cultural hospitality.
*The Summer Joy Lucky Draw (Trade Promotion Competition Licence Number: 61599) will be held from 3 July to 31 August 2026. Terms and conditions apply. For eligibility, registration procedures and promotion details, please visit https://www.oceanpark.com.hk/en/a-day-at-the-park/events/summer-joy-lucky-draw
# Terms and conditions apply. For information of the Summer Duo Pass, please visit: https://www.oceanpark.com.hk/en/ticket-offer/admission-ticket-special-offers
Hashtag: #OceanPark
The issuer is solely responsible for the content of this announcement.
Media OutReach
Nanyang Optical Co. Pte Ltd (In Liquidation) Announces Tender Sale of Optical Inventory Located in Shenzhen, China
https://www.instagram.com/rkco_pte_ltd
The issuer is solely responsible for the content of this announcement.
Robert Khan & Co Pte Ltd
We are a team of International Business Assets Consultants focused on the marketing & valuation of unique & interesting projects. We believe that “Valuation is more Art than Science”. Every asset, machine or even a piece of jewellery is unique and imbued with their own story. With over 20 years of experience uncovering unique stories across an exhaustive range of asset classes, we offer our clients our experienced eye, keen ears and interested heart to curate projects and realise their project objectives. Our services include valuation, marketing & sale of various asset classes locally and internationally.
Media OutReach
Hong Kong Disneyland Continues to Enhance Guest Experience Through Flexible Weather Adaptation Measures
From cooling facilities and shaded rest areas to flexible operational arrangements, the initiatives are designed to provide more choices and added ease for both guests and cast members during the summer months.
Additionally, HKDL has introduced an exclusive “Summer Chill” 4PM Ticket Offer for Hong Kong residents. Guests can enjoy the park from 4:00pm onwards, helping them avoid the hottest hours or periods of heavy rain, with prices starting at just HK$480.
Guests are also encouraged to stay hydrated and explore the resort’s wide selection of indoor attractions and entertainment offerings during the hottest hours of the day.
Weather-Conscious Design for a Better Guest Experience
The guest experience is supported by the resort’s planning and operations through a combination of environmental design and infrastructure enhancements. Disney Imagineers use detailed studies of sunlight, temperature, humidity and wind, supported by advanced computer simulations, to assess conditions across different areas of the park and guide design decisions.
For instance, Wayfinders’ Table in Adventureland was designed with sun exposure and ventilation needs in mind. Through the use of hard roof materials and thoughtful airflow planning, the design helps reduce heat buildup while providing shelter from rain.
Canopies, trees and fans are also used for the outdoor stage show “Moana: A Homecoming Celebration” to provide shade and added relief. The park also preserves and plants trees more extensively to provide additional natural shade.
Enhancing Infrastructure to Adapt to Changing Weather Conditions
HKDL has strengthened its guest-focused infrastructure to help improve airflow and provide added cooling support in various summer weather conditions. Energy-efficient ceiling fans operate at entrances and ticketing areas, while upgraded axial fans enhance airflow in queuing zones.
The park now features approximately 860 fans, with mobile units deployed flexibly to provide cooling support where they are needed most, particularly in high-traffic areas. Portable air-conditioning units have also been added in select outdoor zones to further support ventilation.
Mist cooling systems are also available at multiple outdoor locations, while additional shade structures have been added to queuing and dining areas.
Over 40 free water dispensers are provided across the resort, with nearly half already upgraded to dispense water 50% faster, helping guests rehydrate more conveniently throughout their visit.
Supporting Cast Members Through Changing Weather Conditions
With cast member safety as a top priority, HKDL continuously reviews operational measures to support frontline teams working outdoors in varying weather conditions. Cast members are dressed in outdoor costumes made with breathable, moisture-wicking fabrics, while additional rest breaks, hydration support and access to cooling facilities are provided during periods of extreme heat and humidity.
The resort closely monitors weather conditions and proactively adjusts outdoor show schedules whenever Heat Stress at Work Warnings are issued.
Disney Ambassadors also distribute electrolyte drink powder and chilled water bottles to frontline cast members working in outdoor areas.
Cooling Fun with Pixar Summer Fest
HKDL integrates cooling moments into storytelling. Guests can conveniently transition between a wide variety of indoor attractions, dining venues and entertainment offerings located throughout the resort, helping the magic continue in changing weather conditions.
The newly launched “Pixar Summer Fest” invites guests to beat the heat with immersive entertainment. The “Pixar Water Play Street Party!” welcomes guests to join beloved Pixar characters in a lively water parade, offering refreshing fun as part of the festive atmosphere.
Guests can also chill out with refreshing Pixar-themed treats, including Lime Dole Whip with Pineapple Slush Float at Jessie’s Snack Roundup, Monsters, Inc.-inspired Mike Wazowski Ice Cream Bar, Toy Story Alien Ice Cream Bar, and Sulley-inspired Mint Chocolate Flavored Soft Serve. These playful creations offer visual delight and refreshing summer treats for guests.
Exclusively for Hong Kong residents, the “Summer Chill” 4PM Ticket offers later entry to the park for just HK$480, allowing guests to enjoy an afternoon-to-evening “Pixar Summer Fest” experience.
Hashtag: #HongKongDisneyland
The issuer is solely responsible for the content of this announcement.
