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Triple agonist UBT251 delivers up to 19.7% mean weight loss after 24 weeks in phase 2 trial in China

Published

3 weeks ago

24/02/2026

UBT251 is a triple agonist of the receptors for GLP-1, GIP and glucagon (triple G), being jointly developed by United Biotechnology and Novo Nordisk
In a placebo-controlled phase 2 trial in Chinese people with overweight or obesity, UBT251 led to a statistically significant mean weight loss of up to 19.7% after 24 weeks
UBT251 appeared to have a safe and well-tolerated profile consistent with incretin-based therapies.

GUANGDONG, CHINA & BAGSVÆRD, DENMARK – Media OutReach Newswire – 24 February 2026 – The United Laboratories International Holdings Limited (TUL) and Novo Nordisk A/S (Novo Nordisk) today announced topline results from a Chinese phase 2 trial of UBT251, a triple agonist of the receptors for GLP-1, GIP, and glucagon (triple G).

UBT251 is being jointly developed by TUL’s wholly-owned subsidiary The United Bio-Technology (Hengqin) Co., Ltd. (United Biotechnology) and Novo Nordisk under an agreement signed in March 2025. United Biotechnology is responsible for development in Chinese mainland, Hong Kong, Macau and Taiwan, while Novo Nordisk is responsible for development in the rest of the world.

The trial, conducted by United Biotechnology, investigated the safety and efficacy of once-weekly injectable 2 mg, 4 mg and 6 mg doses of UBT251 compared to placebo in Chinese people with overweight or obesity. From a baseline mean body weight of 92.2 kg, the highest mean weight loss observed for people treated with UBT251 was 19.7% (-17.5 kg) compared to 2.0% (-1.6kg) in the placebo group after 24 weeks of treatment[i].

Moreover, all dose groups of UBT251 showed statistically significant improvements relative to placebo on key secondary endpoints, including waist circumference, blood glucose, blood pressure and lipids.

In the trial, UBT251 appeared to have a safe and well-tolerated profile. The most common adverse events were gastrointestinal, and the vast majority were mild to moderate and diminished over time, consistent with incretin-based therapies.

“The success of the phase 2 clinical trial of UBT251 in China represents another significant milestone in TUL’s innovation-driven development,” said Mr Tsoi Hoi Shan, Chairman of TUL. “We will continue to focus on chronic diseases, including endocrine and metabolic disorders, accelerate the further development of UBT251, and strive to bring more high-quality treatment options to patients worldwide at the earliest opportunity.”

“We are very encouraged by these data from the trial in China, which demonstrate the potential of UBT251 and its differentiated clinical profile and safety and tolerability profile,” said Martin Holst Lange, executive vice president, chief scientific officer and head of Research and Development at Novo Nordisk. “We look forward to reporting data from a global trial with UBT251 conducted by Novo Nordisk next year.”

Novo Nordisk recently initiated a global phase 1b/2a trial investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of different doses of UBT251 for up to 28 weeks in around 330 people living with overweight or obesity. Topline data from that trial is expected in 2027. Novo Nordisk also expects to initiate a phase 2 trial with UBT251 in people with type 2 diabetes in the second half of 2026.

United Biotechnology will present detailed data from the Chinese phase 2 trial at a medical congress later this year. Based on the results of this trial, the company is planning to initiate a phase 3 trial in Chinese patients with overweight or obesity.

About the Chinese phase 2 trial

This randomized, double-blind, placebo-controlled trial enrolled a total of 205 Chinese patients with obesity (BMI ≥ 28.0 kg/m²) or overweight (24.0 kg/m² ≤ BMI < 28.0 kg/m²) with at least one weight-related comorbidity. The baseline mean body weight of the patients was 92.2 kg, with a baseline mean BMI of 33.1 kg/m².

Patients were randomly assigned to receive weekly subcutaneous injections of UBT251 in doses of 2 mg, 4 mg, 6 mg, or placebo for 24 weeks.

The primary endpoint of the trial was the percentage change in body weight from baseline after 24 weeks of treatment.

About UBT251

UBT251 is a long-acting synthetic peptide triple agonist targeting the receptors for GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide) and glucagon.

In March 2025, United Biotechnology entered an exclusive license agreement with Novo Nordisk A/S for UBT251. Under the agreement, Novo Nordisk obtained exclusive worldwide rights (excluding Chinese mainland, Hong Kong, Macau, and Taiwan) to develop, manufacture and commercialise UBT251. United Biotechnology retained the rights for UBT251 in Chinese mainland, Hong Kong, Macau and Taiwan.

[i] Based on the efficacy estimand according to the trial protocol, regardless of dose modification

Hashtag: #UBT251

The issuer is solely responsible for the content of this announcement.

About TUL and United Biotechnology

Founded in 1990, TUL (HKEX: 3933) is mainly engaged in the research and development, production and sales of pharmaceuticals, and ranks among the leading integrated pharmaceutical companies in China. TUL currently boasts seven production bases, covering intermediate products, bulk medicine, finished products, veterinary drugs, empty capsule casings, and medical devices, with the sales networks dotted across nearly 80 countries and regions. United Biotechnology, located in the Guangdong-Macao In-Depth Cooperation Zone in Hengqin, serves as the biopharmaceutical R&D headquarter of TUL. United Biotechnology focuses on the development of high-end biopharmaceuticals to treat major chronic diseases. For more information, please visit www.tul.com.cn.

About Novo Nordisk

Novo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat serious chronic diseases, built upon our heritage in diabetes. We do so by pioneering scientific breakthroughs, expanding access to our medicines, and working to prevent and ultimately cure disease. Novo Nordisk employs about 68,800 people in 80 countries and markets its products in around 170 countries. For more information, visit novonordisk.com, YouTube.

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The CHANGAN DEEPAL S05 Arrives in the UK—Engineered Globally, Tuned Locally

Published

14 hours ago

14/03/2026

Media Outreach

Long range, premium comfort, and five-star safety—the CHANGAN DEEPAL S05 delivers a high-tech electric driving experience.
Cutting-edge EV technology that brings together global design, engineering, and manufacturing.

BIRMINGHAM, UK – Media OutReach Newswire – 14 March 2026 – Changan UK has launched the all-electric CHANGAN DEEPAL S05, a compact C-SUV blending premium design, intelligent technology, and everyday practicality.

“The CHANGAN DEEPAL S05 is designed for people who want an electric SUV that fits effortlessly into everyday life,” Nic Thomas, Managing Director of Changan UK, said, “It delivers reassuring performance, thoughtful comfort, and technology that simply works—all without the premium price tag. ”

The CHANGAN DEEPAL S05: Range, Comfort, Safety

Powered by a 68.8kWh LFP battery, the CHANGAN DEEPAL S05 delivers WLTP ranges of up to 303 miles (RWD) and 278 miles (AWD). Inside, the aircraft-inspired cockpit features vegan leather heated and ventilated front seats, including a full-recline zero gravity passenger seat. A 15.4-inch rotating touchscreen, AR-HUD, 14-speaker audio system, and wireless smartphone connectivity complete the high-tech cabin.

Safety is central to the CHANGAN DEEPAL S05, earning it a five-star Euro NCAP rating. It comes standard with 17 intelligent driver assistance systems, enabling L2 autonomous driving through a network of cameras, radars, and ultrasonic sensors—including a 540-degree surround-view camera system.

More Than a Model: How the CHANGAN DEEPAL S05 Embodies a Global Vision

Changan is now present in 16 European markets, with launches in Italy, Spain, and Poland coming soon. The UK anchors this footprint as a strategic hub for local development. Leading this momentum is the CHANGAN DEEPAL S05, a model built on a truly global foundation. Designed at Changan Design Center Europe in Turin and calibrated at the Changan UK R&D Centre in Birmingham, it has been meticulously tuned for local roads.

For the UK market, the CHANGAN DEEPAL S05 is produced at Changan Rayong Factory in Thailand—established in 2023 as a dedicated hub for global right-hand drive markets. With approximately 60% local sourcing, the facility ensures consistent quality, testing, and supply, while its strategic location enables worldwide logistics. More than a new model, the S05 stands as a testament to Changan’s global ambitions—integrating design, engineering, and production across continents to deliver a truly international electric vehicle.

Hashtag: #Changan

The issuer is solely responsible for the content of this announcement.

Media OutReach

The Hong Kong Institution of Engineers 50th Anniversary “Together we RISE” Carnival Opens

Published

21 hours ago

14/03/2026

Media Outreach

Featuring Over 40 Interactive and Game Booths Showcasing Engineering Innovation

HONG KONG SAR – Media OutReach Newswire – 14 March 2026 – To celebrate its 50^th Anniversary, The Hong Kong Institution of Engineers (hereafter “the HKIE”) has organised “The HKIE ‘Together we RISE’ Carnival” (hereafter “the Carnival”) at High Lawn, Art Park, WestK. The opening ceremony took place today, officiated by Ms Bernadette LINN Hon Ho, JP, Secretary for Development of the HKSAR Government; Mr YE Shuiqiu, Deputy Director-General of the Department of Educational, Scientific and Technological Affairs of the Liaison Office of the Central People’s Government in the Hong Kong Special Administrative Region; Ir Ricky LAU Chun Kit, JP, Permanent Secretary for Development (Works); and Ir The Hon Aaron BOK Kwok Ming, Legislative Council Member (Functional Constituency – Engineering) cum Past President of the HKIE. They were joined by Ir Alice CHOW, President of the HKIE; Ir Prof Frank CHAN Fan, GBS, JP, Senior Vice President of the HKIE; Ir Rupert LEUNG Kwok Yiu, Vice President of the HKIE; Ir William LUK Wai Lam, Vice President of the HKIE and Ir Prof Alfred SIT Wing Hang, GBS, JP, Chief Executive and Secretary of the HKIE to kick off this two-day event.

Group Photo of officiating guests at the Opening Ceremony, including Ms Bernadette LINN Hon Ho, JP, Secretary for Development(4th right); Mr YE Shuiqiu, Deputy Director-General of the Department of Educational, Scientific and Technological Affairs of the Liaison Office of the Central People’s Government in the Hong Kong Special Administrative Region(4th left); Ir Ricky LAU Chun Kit, JP, Permanent Secretary for Development (Works) (3rd left); Ir The Hon Aaron BOK Kwok Ming, Legislative Council Member (Functional Constituency – Engineering) cum Past President of the HKIE(3rd right); Ir Alice CHOW, President of the HKIE(middle); Ir Prof Frank CHAN Fan, GBS, JP, Senior Vice President of the HKIE (2nd left); Ir Rupert LEUNG Kwok Yiu, Vice President of the HKIE(2nd right); Ir William LUK Wai Lam, Vice President of the HKIE(1st right); and Ir Prof Alfred SIT Wing Hang, GBS, JP, Chief Executive and Secretary of the HKIE(1st left).

With the theme “Together we RISE”, the Carnival aims to highlight the engineering profession’s outstanding contributions to social progress, technological innovation, and sustainable development. Running from 14-15 March, the Carnival features over 40 interactive booths and game zones designed by various organisations and HKIE divisions. The booths showcase exciting innovations including robot and robot dog demonstrations, model displays, VR experiences, UAV flight simulators, a water pumping robot, and more, offering enjoyable, hands-on exploration of the diversity and fun of engineering for the whole family over the weekend.

The Carnival also features a travelling exhibition, “Engineering Legacy: 50 Years of Excellence”, celebrating 19 excellent engineering projects honoured with The HKIE 50th Anniversary Legacy Award. The exhibition highlights the remarkable achievements and milestones that have shaped Hong Kong’s engineering landscape over the past five decades. In addition, the winning entries from the “Together we RISE” school competition held by the HKIE earlier will be showcased, reflecting the creativity and imagination of the younger generation in building sustainable and innovative cities.

Ir Alice CHOW, President of The Hong Kong Institution of Engineers, remarked, “The Hong Kong Institution of Engineers has grown alongside Hong Kong over the past 50 years, witnessing and contributing to many of the city’s landmark infrastructure and urban development projects. Through the Carnival, we hope the public can gain a deeper understanding of the vital role engineers play in society, while inspiring the younger generation’s interest and creativity in the engineering profession. ‘Together we RISE’ is not just a theme; it also expresses our commitment to fostering innovation, uniting the industry, and building the future, leveraging Hong Kong’s unique advantages of being ‘backed by our motherland and connected to the world’!”

The HKIE 50^th Anniversary “Together we RISE” Carnival

Date and time:

14 March 2026 (Sat) 10am-6pm

15 March 2026 (Sun) 10am-6pm

Location:

High Lawn, Art Park, WestK

Fee:

Free of charge

Hashtag: #HKIE

The issuer is solely responsible for the content of this announcement.

About the HKIE

The Hong Kong Institution of Engineers (HKIE) – previously The Engineering Society of Hong Kong – was founded in 1947. In 1975, the HKIE was incorporated under The Hong Kong Institution of Engineers Ordinance, Chapter 1105 of the Laws of Hong Kong. Today the HKIE has over 32,000 members, of which around 17,000 are Corporate Members.

The Institution aims to bring together engineers of different disciplines for their common good. The HKIE is committed to upholding the quality of membership, and sets standards for the training and admission of engineers from 22 engineering disciplines. It also has strict rules governing members’ conduct and is dedicated to raising the ethical standards of professional engineers in Hong Kong. For more information about the HKIE, please visit https://hkie.org.hk

Media OutReach

AIA Alta Prestige Wealth Centre Opens at AIA Central

Published

21 hours ago

14/03/2026

Media Outreach

Elevating the High-Net-Worth and Ultra-High Net-Worth Experience through Orchestrated Wealth and Legacy Advisory

HONG KONG SAR – Media OutReach Newswire – 14 March 2026 – AIA Hong Kong announced the opening of the AIA Alta Prestige Wealth Centre at AIA Central, marking a significant milestone in the evolution of AIA Alta, its exclusive proposition for High‑Net‑Worth (HNW)¹ and Ultra‑High‑Net‑Worth (UHNW) customers². Purpose‑built in Central, the Centre is housed within AIA Central—a landmark commercial building wholly owned by AIA Group—at the heart of the city’s financial district. The Centre is designed to serve customers with increasingly complex, multi‑market wealth, health and legacy planning needs through a highly integrated and personalised advisory experience.

Mr Lee Yuan Siong, AIA Group Chief Executive and President (fourth from left); Mr Jacky Chan, AIA Regional Chief Executive and Group Chief Distribution Officer (fourth from right); Mr Alger Fung, Chief Executive Officer, AIA Hong Kong & Macau (third from left); Ms Alice Liang, Chief Proposition & Healthcare Officer, AIA Hong Kong & Macau (third from right); Ms Amy Chan, Chief Agency Officer, AIA Hong Kong & Macau (second from left); Ms Myra Lee, Chief Financial Officer, AIA Hong Kong & Macau (second from right); Ms Melissa Wong, Chief Customer & Marketing Officer, AIA Hong Kong & Macau (first from left); and Ms Carol Li, Chief Life Officer (first from right), AIA Hong Kong & Macau, celebrated the opening of the AIA Alta Prestige Wealth Centre.

Alice Liang, Chief Proposition & Healthcare Officer of AIA Hong Kong & Macau, said: “Since 2023, we have continued to strengthen our HNW proposition and see strong growth potential in this segment. In an increasingly dynamic global environment, enduring wealth, health and legacy planning have become more critical than ever.

Ms Alice Liang, Chief Proposition & Healthcare Officer of AIA Hong Kong & Macau, said that AIA Alta is extending its proposition to the UHNW segment, with the opening of the AIA Alta Prestige Wealth Centre marking a pivotal step in this journey.

We are elevating the HNW experience and expanding into the UHNW market as these customers seek more than insurance—looking for coordinated wealth and legacy advisory from a long-term partner who can guide them through complexity with clarity and confidence. The opening of the AIA Alta Prestige Wealth Centre is a pivotal step, supported by our HNW Dedicated Team and international partners, to help customers achieve an optimal balance of health and wealth.”

At the Heart of Hong Kong’s Financial District

Formerly known as the AIA Alta Wealth Management Centre in Causeway Bay, the Centre was established as the first^# of its kind within Hong Kong’s insurance industry to provide professional wealth management services. Now housed within AIA Central, the AIA Alta Prestige Wealth Centre^& offers unparalleled proximity to the city’s financial ecosystem. This strategic location enables seamless connection with private banks, professional firms and international institutions that play a critical role in multi‑market wealth structuring and legacy planning.

The AIA Alta Prestige Wealth Centre is designed to serve HNW and UHNW customers with increasingly complex, multi market wealth, health and legacy planning needs through a highly integrated and personalised advisory experience.(1)

A Refined Advisory Experience

The Centre has been purpose‑designed to deliver a more orchestrated and holistic advisory experience. Supported by AIA’s HNW Dedicated Team and a network of international organisations, HNW customers can access advisory services on trust, legacy, tax, legal and family office matters within a single private setting. By bringing these capabilities together across every stage of the wealth and legacy planning journey, the Centre reduces fragmentation and empowers customers to make more confident, informed decisions.

A distinctive feature of the Centre is its bespoke hospitality offering, with dining prepared by AIA’s own corporate dining team. Thoughtfully curated food and beverage selections complement advisory engagements within a calm and private environment. Visitors may also explore the History Wall, which traces AIA Group’s century‑long legacy in Asia and its enduring commitment to customers across generations, while enjoying panoramic views of Victoria Harbour, taking in Hong Kong’s iconic skyline and landmarks such as the Hong Kong Observation Wheel.

*Guests can enjoy panoramic views of Victoria Harbour, taking in Hong Kong’s iconic skyline and landmarks.*

Purpose‑Led Design

Guided by AIA’s commitment to sustainability, the Centre’s design reflects ESG‑informed principles through material storytelling. Reclaimed elements—from ocean‑recovered fragments to repurposed glass, metal and wood—are thoughtfully re‑crafted to symbolise restoration, renewal and continuity, expressing AIA Alta’s belief that sustainability is a lived philosophy that preserves value, honours origins and supports enduring legacies across generations.

A Trusted Proposition for HNW Families

The strength of the AIA Alta proposition is underpinned by strong customer recognition. For years, AIA has been recognised as Hong Kong’s most popular insurance brand among HNW individuals^%, reflecting sustained trust in its ability to support HNW families. Looking ahead, AIA Alta will continue to support customers through its integrated pillars of Wealth and Health, complemented by meaningful experiences and curated privileges offered through AIA Alta Club—empowering customers to truly live Healthier, Longer, Better Lives.

*Visitors may also explore the History Wall, which traces AIA Group’s century long legacy in Asia and its enduring commitment to customers across generations.*

Remarks:

1 High‑Net‑Worth customer means a customer with investable wealth of US$1 million to US$30 million.

2 Ultra‑High‑Net‑Worth customer means a customer with investable wealth of more than US$30 million.

# As of 1 March 2023, compared with similar services offered by major Hong Kong insurance companies.

& AIA Alta Prestige Wealth Centre is available by invitation only.

% According to YouGov, an international research and data analytics company, Hong Kong BrandIndex 2022-2025, AIA has been the Most Considered Insurance Brand and is Most Likely to Be Purchased among the High-Net-Worth customers in Hong Kong (individuals with total investable assets exceeding US$ 1 million) for four consecutive years (from 2022 to 2025).

Important Information:

The above information provided herein shall not be construed as providing, selling, or soliciting the purchase of any insurance products or services outside Hong Kong and/or Macau, nor does it constitute any sales advice, product recommendation, or any form of service offer. Where the offering or sale of insurance products is prohibited under the laws of any jurisdiction outside Hong Kong and/or Macau, AIA shall not engage in such activities within that jurisdiction. AIA does not provide or sell insurance products or services in any territory other than Hong Kong and/or Macau. The above information is for reference purposes only and does not include detailed terms, conditions, or risk disclosures associated with the relevant products.
AIA reserves the right to amend, suspend or terminate the Services, any part thereof, service provider(s) or change any terms and conditions relating thereto at any time without prior notice at its absolute discretion.

Hashtag: #AIA

The issuer is solely responsible for the content of this announcement.

About AIA Hong Kong & Macau

AIA Group Limited established its operations in Hong Kong in 1931. To date, AIA Hong Kong and AIA Macau have about 18,000 financial planners^*, as well as an extensive network of independent financial advisors, brokerage and bancassurance partners. We serve over 3.6 million customers^{^}, offering them a wide selection of professional services and products ranging from individual life, group life, accident, medical and health, pension, personal lines insurance to investment-linked assurance schemes with numerous investment options. We are also dedicated to providing superb product solutions to meet the financial needs of high-net-worth customers.

^* As at 30 June 2025
^{^} Including AIA Hong Kong and AIA Macau’s individual life, group insurance and pension customers (as at 30 June 2025)