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CK Life Sciences Files Patent Applications for Circular mRNA TROP2 Cancer Vaccine

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Breast Cancer Animal Studies Show Unprecedented Anti-Cancer Efficacy of 100% Tumor Growth Inhibition

HONG KONG SAR – Media OutReach Newswire – 11 April 2025 – CK Life Sciences Int’l., (Holdings) Inc. (“CK Life Sciences”), a leader in cancer vaccine development, announces the latest progress in its pharmaceutical R&D, namely the filing of an Original Grant Patent application in Hong Kong and a provisional patent application in the United States for novel cancer vaccines targeting Trophoblast Cell Surface Antigen 2 (“TROP2”).

TROP2 is a cell surface glycoprotein that is overexpressed in a wide range of cancers, including breast, lung, pancreatic, and colorectal cancers. This protein plays a critical role in cell proliferation, migration, and invasion, and its overexpression is frequently linked to aggressive tumor behavior and poor clinical outcomes. Given its high expression in cancer cells and minimal presence in normal tissues, TROP2 has emerged as a promising therapeutic target in oncology.

TROP2-positive triple-negative breast cancer animal study demonstrated 100% tumor growth inhibition

TROP2 cancer vaccines covered by the patent application include innovative circular mRNA (circRNA) and fusion protein vaccine constructs that can induce robust T cell immune responses and have demonstrated impressive tumor growth inhibition in preclinical studies of triple-negative breast cancer and colorectal cancer. The results of animal studies involving triple-negative breast cancer (“TNBC”) have been encouraging, with mouse models showing 100% tumor growth inhibition after receiving the TROP2 cancer vaccine. Overall, 100% inhibition of tumor growth was achieved in four of the five studies when mice were treated with a TROP2 vaccine candidate, while the remaining study demonstrated approximately 80% tumor growth inhibition.

Triple-negative breast cancer disproportionately prevalent and aggressive among Asian women

The results of animal studies of the TROP2 cancer vaccines are of particular relevance to the Asian region. Breast cancer rates in Asia are rising sharply, with younger women widely affected. In particular, TNBC shows both higher prevalence and more aggressive behavior in Asian populations compared to Western counterparts. Additionally, TNBC has fewer treatment options and demonstrates significantly higher rates of metastasis and recurrence than other breast cancer subtypes.

Unprecedented anti-cancer efficacy

“TROP2 is an exciting therapeutic target and preclinical studies of our cancer vaccine in triple-negative breast cancer exhibited 100% inhibition of tumor growth, demonstrating unprecedented anti-cancer efficacy. We look forward to advancing our TROP2 cancer vaccine expeditiously into clinical trials to benefit patients and believe it holds significant potential in preventing cancer recurrence,” said Dr. Melvin Toh, Chief Scientific Officer at CK Life Sciences.

Data on the TROP2 cancer vaccines will be presented at upcoming cancer conferences. In recent years, CK Life Sciences has showcased its growing early-stage cancer vaccine pipeline through preclinical data presentations at leading oncology conferences, alongside the filing of multiple patents. Developed in its Hong Kong-based R&D laboratories, these innovative vaccines target a broad spectrum of tumor antigens, immune checkpoint proteins, and other key components within the tumor-immune microenvironment.

Hashtag: #CKLifeSciences #CancerVaccines #R&D #BreastCancer #PatentApplication #Pharmaceutical

The issuer is solely responsible for the content of this announcement.

About CK Life Sciences

CK Life Sciences Int’l., (Holdings) Inc. (stock code: 0775) is listed on the Stock Exchange of Hong Kong. With a mission of improving the quality of life, CK Life Sciences is engaged in healthcare research and development, with operating businesses that enable its R&D sustainability. Regarding pharmaceutical research and development, CK Life Sciences’ operations are focused on conducting research and development into cancer vaccines and pain management solutions. CK Life Sciences is a member of the CK Hutchison Group. For additional information, please visit .

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AEON Bank Helps Ease Festive Season’s Budget Constraints with No-Hassle Personal Financing-i

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KUALA LUMPUR, MALAYSIA – Media OutReach Newswire – 24 December 2025 – As Malaysians gear up for multiple financial commitments in the upcoming weeks and months, especially during the year-end holidays, back-to-school and double festive season, AEON Bank (M) Berhad, Malaysia’s first digital Islamic bank, strengthens its commitment to financial inclusion by offering accessible support through its Personal Financing-i (PF-i).

From December 2025 till March 2026, the bustling seasons present convergence of multiple spending needs for many households. Acknowledging that this might raise the need for flexible liquidity, AEON Bank provides a solution to address such budgetary constraints in the form of the PF-i; an inclusive, hassle-free financing facility, easily accessible via its digital banking app.

Optimising a Risk-Based Pricing (RBP) framework to determine a competitive and personalised profit rate, AEON Bank ensures that customers can seamlessly apply for PF-i online, as long as they are Malaysian citizens aged 18 to 55, with a minimum monthly gross income of RM2,500 – be it salaried employees or self-employed individuals, freelancers, as well as gig economy workers.

Aligned with Shariah banking principles, PF-i offers financing facility from RM1,000 up to RM100,000 with flexible tenure options ranging from 3 to 84 months, allowing for repayments tailored to individual budget needs. The Flat Profit Rate starting from 3.88% p.a. and a nominal Wakalah Fee of RM1 is applicable upon acceptance.

The entire process, from the application to fund disbursement are all managed online via the AEON Bank app. This simplifies the process and eliminates the need for physical paperwork or branch visits. To apply for PF-i, customers simply need to follow these steps :

  • Step 1 : Activated Savings Account-i pre-requisite

Download the AEON Bank app and activate the Savings Account-i, prior to applying for PF-i.

  • Step 2 : Eligibility check and employment details

Applicants must be Malaysian citizens aged 18 and above, earning a minimum monthly gross income of RM2,500 – either as salaried employees, self-employed or gig workers.

  • Step 3 : Financing selection

Select the preferred financing amount ranging from RM1,000 up to RM100,000 and flexible repayment tenure, with options between 3 to 84 months.

  • Step 4 : Supporting document submission

Upload the latest EPF (KWSP) statement, reflecting the latest consecutive 6-months contributions (for salaried workers) or latest consecutive 6-month bank statement (for self-employed/gig workers).

  • Step 5 : Approval and fund disbursement

Applications will be processed immediately and upon approval, funds will be disbursed directly into the applicant’s AEON Bank Savings Account-i. Repayments will be automatically deducted via monthly auto-debit.

PF-i enables Malaysians to access a Shariah compliant financing facility to ease their needs; be it an emergency financial support, family budget constraint, small renovation, vehicle repair or a much needed financial aid to bridge the temporary cashflow gaps.

For comprehensive details on the Personal Financing-i (PF-i), including full terms and conditions, click here to browse the website and scan the QR Code to download the AEON Bank app: https://www.aeonbank.com.my/api/qr-handler

Hashtag: #AEONBank #DigitalBanking #IslamicDigitalBank #ShariahCompliant #FinancialInclusion #IslamicFintech #PersonalFinancing





The issuer is solely responsible for the content of this announcement.

AEON Bank (M) Berhad

AEON Bank (M) Berhad is the first digital Islamic bank in Malaysia, licensed and regulated by Bank Negara Malaysia and the Ministry of Finance. Officially launched on 26 May 2024, we currently offer a suite of Shariah-compliant products and services under the Personal Banking and Business Banking (AEON Bank Biz).

Our Personal Banking offerings are 100% accessible via the AEON Bank app, namely the deposit Savings Account-i, AEON Bank x Visa Debit Card-i, Personal Financing-i, Term Deposit-i, Savings Pots, DuitNow QR, utility bill payments, personal financial management and budgeting tools with Neko Sensei, and a range of digital payment services with strategic partners and merchants, as well as Neko Missions, Malaysia’s first gamified digital banking interactive rewards programme.

On 8 August 2025, AEON Bank (M) Berhad officially launched AEON Bank Biz, anchored by the Current Business Account-i and integrated cash management capabilities, with the initial onboarding of vendors from AEON Credit Service (M) Berhad and suppliers within the broader AEON ecosystem. The targeted approach is designed to create an integrated value chain linking AEON’s retail and financial services networks, supporting strategic growth and greater inclusivity. AEON Bank Biz offers streamlined processes for account onboarding, credit assessments and financial services, utilising AI-driven fintech solutions to enable simplified procedures, faster approvals, and an enhanced digital banking experience for business owners and entrepreneurs. AEON Bank Biz’s products and services will soon be extended to more local businesses and entrepreneurs across Malaysia.

Being part of the AEON Group conglomerate, AEON Bank (M) Berhad is equally held by AEON Financial Service Co. Ltd. (AFS Japan) and AEON Credit Service (M) Berhad (ACSM). AFS Japan is responsible for the AEON Group’s financial services businesses, with strong roots in the retail sector which operates in Japan and 10 countries across Asia and it is. AEON Group is Japan’s largest retail group and it is a pure holding company that comprises eight core businesses.

AEON Group Malaysia consists of several entities, namely, AEON Co. (M) Bhd, AEON Credit Service (M) Berhad, AEON Bank (M) Berhad, AEON BiG (M) Sdn Bhd, AEON Fantasy (M) Sdn Bhd, AEON Delight (M) Sdn Bhd, AEON Global Supply Chain Sdn Bhd and Malaysian AEON Foundation (MAF). AEON Group has been a recognizable household brand with more than 200 years of history and evolution in Japan since the Edo era, along with 4 decades of growth in Malaysia, providing consumers with daily financial solutions and diversified retail convenience.

Our cloud native agility and AI optimisation, combined with the strength of our Shariah DNA, Malaysian roots and Japanese heritage are our distinguishing factors, while the integration with the AEON ecosystem gives us a competitive advantage of being the only bank in Malaysia with its own nationwide retail network. On top of that, AEON Points loyalty programme offers customers value-added benefits and meaningful rewards, as the AEON Points can be redeemed into cash value, deposited directly into customers’ AEON Bank Savings Account-i.

AEON Bank (M) Berhad is committed to provide accessible financial solutions for Malaysians and we aim to empower the community in pursuing their financial aspirations and achieve economic independence, hence fostering a more inclusive financial future for all. We will continue to contribute towards the Islamic banking development in the region and the nation’s digital economy.

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AEON Bank Helps Ease Festive Season’s Budget Constraints with No-Hassle Personal Financing-i

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KUALA LUMPUR, MALAYSIA – Media OutReach Newswire – 24 December 2025 – As Malaysians gear up for multiple financial commitments in the upcoming weeks and months, especially during the year-end holidays, back-to-school and double festive season, AEON Bank (M) Berhad, Malaysia’s first digital Islamic bank, strengthens its commitment to financial inclusion by offering accessible support through its Personal Financing-i (PF-i).

From December 2025 till March 2026, the bustling seasons present convergence of multiple spending needs for many households. Acknowledging that this might raise the need for flexible liquidity, AEON Bank provides a solution to address such budgetary constraints in the form of the PF-i; an inclusive, hassle-free financing facility, easily accessible via its digital banking app.

Optimising a Risk-Based Pricing (RBP) framework to determine a competitive and personalised profit rate, AEON Bank ensures that customers can seamlessly apply for PF-i online, as long as they are Malaysian citizens aged 18 to 55, with a minimum monthly gross income of RM2,500 – be it salaried employees or self-employed individuals, freelancers, as well as gig economy workers.

Aligned with Shariah banking principles, PF-i offers financing facility from RM1,000 up to RM100,000 with flexible tenure options ranging from 3 to 84 months, allowing for repayments tailored to individual budget needs. The Flat Profit Rate starting from 3.88% p.a. and a nominal Wakalah Fee of RM1 is applicable upon acceptance.

The entire process, from the application to fund disbursement are all managed online via the AEON Bank app. This simplifies the process and eliminates the need for physical paperwork or branch visits. To apply for PF-i, customers simply need to follow these steps :

  • Step 1 : Activated Savings Account-i pre-requisite

Download the AEON Bank app and activate the Savings Account-i, prior to applying for PF-i.

  • Step 2 : Eligibility check and employment details

Applicants must be Malaysian citizens aged 18 and above, earning a minimum monthly gross income of RM2,500 – either as salaried employees, self-employed or gig workers.

  • Step 3 : Financing selection

Select the preferred financing amount ranging from RM1,000 up to RM100,000 and flexible repayment tenure, with options between 3 to 84 months.

  • Step 4 : Supporting document submission

Upload the latest EPF (KWSP) statement, reflecting the latest consecutive 6-months contributions (for salaried workers) or latest consecutive 6-month bank statement (for self-employed/gig workers).

  • Step 5 : Approval and fund disbursement

Applications will be processed immediately and upon approval, funds will be disbursed directly into the applicant’s AEON Bank Savings Account-i. Repayments will be automatically deducted via monthly auto-debit.

PF-i enables Malaysians to access a Shariah compliant financing facility to ease their needs; be it an emergency financial support, family budget constraint, small renovation, vehicle repair or a much needed financial aid to bridge the temporary cashflow gaps.

For comprehensive details on the Personal Financing-i (PF-i), including full terms and conditions, click here to browse the website and scan the QR Code to download the AEON Bank app: https://www.aeonbank.com.my/api/qr-handler

Hashtag: #AEONBank #DigitalBanking #IslamicDigitalBank #ShariahCompliant #FinancialInclusion #IslamicFintech #PersonalFinancing





The issuer is solely responsible for the content of this announcement.

AEON Bank (M) Berhad

AEON Bank (M) Berhad is the first digital Islamic bank in Malaysia, licensed and regulated by Bank Negara Malaysia and the Ministry of Finance. Officially launched on 26 May 2024, we currently offer a suite of Shariah-compliant products and services under the Personal Banking and Business Banking (AEON Bank Biz).

Our Personal Banking offerings are 100% accessible via the AEON Bank app, namely the deposit Savings Account-i, AEON Bank x Visa Debit Card-i, Personal Financing-i, Term Deposit-i, Savings Pots, DuitNow QR, utility bill payments, personal financial management and budgeting tools with Neko Sensei, and a range of digital payment services with strategic partners and merchants, as well as Neko Missions, Malaysia’s first gamified digital banking interactive rewards programme.

On 8 August 2025, AEON Bank (M) Berhad officially launched AEON Bank Biz, anchored by the Current Business Account-i and integrated cash management capabilities, with the initial onboarding of vendors from AEON Credit Service (M) Berhad and suppliers within the broader AEON ecosystem. The targeted approach is designed to create an integrated value chain linking AEON’s retail and financial services networks, supporting strategic growth and greater inclusivity. AEON Bank Biz offers streamlined processes for account onboarding, credit assessments and financial services, utilising AI-driven fintech solutions to enable simplified procedures, faster approvals, and an enhanced digital banking experience for business owners and entrepreneurs. AEON Bank Biz’s products and services will soon be extended to more local businesses and entrepreneurs across Malaysia.

Being part of the AEON Group conglomerate, AEON Bank (M) Berhad is equally held by AEON Financial Service Co. Ltd. (AFS Japan) and AEON Credit Service (M) Berhad (ACSM). AFS Japan is responsible for the AEON Group’s financial services businesses, with strong roots in the retail sector which operates in Japan and 10 countries across Asia and it is. AEON Group is Japan’s largest retail group and it is a pure holding company that comprises eight core businesses.

AEON Group Malaysia consists of several entities, namely, AEON Co. (M) Bhd, AEON Credit Service (M) Berhad, AEON Bank (M) Berhad, AEON BiG (M) Sdn Bhd, AEON Fantasy (M) Sdn Bhd, AEON Delight (M) Sdn Bhd, AEON Global Supply Chain Sdn Bhd and Malaysian AEON Foundation (MAF). AEON Group has been a recognizable household brand with more than 200 years of history and evolution in Japan since the Edo era, along with 4 decades of growth in Malaysia, providing consumers with daily financial solutions and diversified retail convenience.

Our cloud native agility and AI optimisation, combined with the strength of our Shariah DNA, Malaysian roots and Japanese heritage are our distinguishing factors, while the integration with the AEON ecosystem gives us a competitive advantage of being the only bank in Malaysia with its own nationwide retail network. On top of that, AEON Points loyalty programme offers customers value-added benefits and meaningful rewards, as the AEON Points can be redeemed into cash value, deposited directly into customers’ AEON Bank Savings Account-i.

AEON Bank (M) Berhad is committed to provide accessible financial solutions for Malaysians and we aim to empower the community in pursuing their financial aspirations and achieve economic independence, hence fostering a more inclusive financial future for all. We will continue to contribute towards the Islamic banking development in the region and the nation’s digital economy.

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Empowering Website Operations Across ASEAN with AI and Teamwork

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Japan’s MONJI+—A WebOps Enablement Platform Inspired by Voices from 77 Countries—Launches Its English Edition

OSAKA, JAPAN – Media OutReach Newswire – 24 December 2025 – ALAKI Inc., celebrating its 15th anniversary, has officially launched the English edition of MONJI+, an evolution of its 2018-born feedback tool MONJI β, now reimagined as a comprehensive WebOps Enablement Platform.

Alongside its free plan, available indefinitely, MONJI+ begins its full-scale expansion into the ASEAN market, helping teams elevate their website operations. In addition, a free Academic Edition is now offered to educational institutions to foster the next generation of web and IT talent.

▶️ Learn more about MONJI+

A Platform Born from 77 Countries of Real-World Insight

Since its launch in Japan in 2018, MONJI β has been adopted by web agencies, corporations, and advertising firms worldwide—across 77 countries and regions—streamlining feedback workflows for website management and development.

In everyday website operations, teams often face:

  • Feedback scattered across tools and channels
  • Miscommunication between internal teams and agencies
  • Unclear priorities that fail to drive results
  • Knowledge loss when members change
  • Valuable learnings buried and forgotten

MONJI+ connects creation, publishing, maintenance, and optimization into a single workflow—eliminating silos and enabling all members to move forward toward shared goals.

▶️ See how MONJI+ transforms your workflow

Since its official launch in Japan in January 2025, MONJI+ has rapidly spread among enterprises and educational institutions. It is increasingly adopted as a practical standard among agencies and in-house teams, improving productivity and measurable outcomes.

Responding to Global Voices – Official Launch of the English Edition

During forums and seminars held alongside the Expo 2025 Osaka, Kansai, Japan, ALAKI engaged with government representatives and industry leaders from around the world.

The feedback was clear: inefficiencies in website operations, lack of improvement cycles, and a shortage of web marketing expertise are universal challenges. But one issue stood out above all—the shortage of skilled web and IT professionals.

Some governments even requested that MONJI+ contribute to national web/IT talent development, not just productivity gains. Following the Expo, inquiries from multiple countries confirmed the demand, prompting the official release of the English edition of MONJI+.

Confidence from SWITCH 2025, and a Vision for What’s Next

As part of its ASEAN expansion, ALAKI visited SWITCH 2025 (Singapore Week of Innovation & Technology), held from October 29–31. Through dialogues with government agencies, corporations, startups, and academic institutions, the importance of website operations productivity and digital talent development was reaffirmed.

Insights from leading ASEAN web and IT innovators will continue to shape the evolution of MONJI+.

Key Benefits of MONJI+

Eliminate inefficiencies and dependency on individuals—enhancing both productivity and performance in website operations.

  • Workflow Efficiency: Centralize feedback and progress tracking to prevent oversights
  • Error Reduction: Detect typos automatically with AI proofreading
  • Results-Oriented: Integration with analytics tools helps identify improvement areas instantly
  • Team Collaboration: Share real-time updates across internal and external members
  • Knowledge Building: Use the Wiki feature to retain expertise and reduce training costs

▶️ Explore MONJI+ features

The Future of “Agentic WebOps” — Powered by Data and AI

MONJI+ evolves beyond a simple management tool—it becomes an AI-driven partner that learns from operational data to support human decision-making and creativity.

Our vision: a human-in-the-loop “Agentic WebOps” environment that helps teams achieve outcomes with AI-assisted decision support.

Available AI Features:

  • AI typo and error detection for feedback
  • AI chatbot assistance

Upcoming AI Features (Examples):

  • Content suggestion and creation
  • Feedback trend analysis and improvement recommendations
  • Design assistance
  • Webpage performance analysis and enhancement
Customer Success Stories
  • Global Marketing Agency (Singapore): “Sharing the same interface greatly improved collaboration across our international offices.”
  • Web Production Agency (Japan): “Centralized feedback management accelerated delivery times by roughly 30%.”
  • E-commerce Company (Japan): “By linking with an analytics tool, we identified key improvement areas instantly—our conversion rate increased by over 20%.”
  • Recruitment Platform (Japan): “With AI detecting typos automatically, our job listing checks became faster and more reliable.”
Vision Video – ‘Pride and Hope for the Web Industry’

Discover how MONJI+ envisions the future of website operations.

▶️ Watch the Vision Video

CEO’s Comment

“Website operations shouldn’t be about chasing scattered messages—it should be about generating results that matter. With MONJI+, we unify feedback, workflow, and analytics, while AI suggests the next strategic move. Our mission is to help ASEAN teams reach outcomes faster and more reliably.”

Yuji Yamauchi, Founder & CEO, ALAKI Inc.

Getting Started

Getting started is easy, with no credit card required. MONJI+ aims to be the shared foundation for website operations, accessible to everyone.

  • Forever-Free Plan: Access essential functions without time limits
  • 30-Day Free Trial: Experience all features in a live environment

▶️ Start your free 30-day trial now

Free “Academic Edition” for Educational Institutions

To empower the next generation of web and IT professionals, MONJI+ offers an Academic Edition free of charge to universities, vocational schools, and online programs. Students and educators can experience real-world website operations, gain practical skills, and collaborate through shared projects.

▶️ Learn more about the Academic Edition

Hashtag: #MONJI+

The issuer is solely responsible for the content of this announcement.

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