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J&J to Give Africa 400 million Doses of Vaccine

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Johnson Johnson vaccine

By Adedapo Adesanya

A United States pharmaceutical company, Johnson & Johnson (J&J), is set to provide up to 400 million doses of its COVID-19 vaccine to African countries.

The US pharmaceutical giant on Monday said the availability of the single-shot vaccine will be subject to national regulatory approvals in the African Union’s 55 member states, with the first shipment expected to arrive in the third quarter of 2021.

According to J&J’s CEO, Mr Alex Gorsky, in a statement, “No one is safe until everyone is safe and we have been committed to equitable and global access to new COVID-19 vaccines.”

“Our support for the COVAX Facility, combined with supplementary agreements with countries and regions, will help accelerate global progress toward ending the COVID-19 pandemic,” he added.

The company said Janssen Pharmaceutica, a J&J subsidiary, had entered into an agreement with the African Vaccine Acquisition Trust (AVAT) to initially make available up to 220 million doses of its vaccine.

AVAT can order an additional 180 million doses for a combined total of up to 400 million doses through 2022.

J&J says its vaccine candidate protects against COVID-19 in broad geographical regions — including those with new variants of the virus.

In a global trial of almost 40,000 people, the J&J vaccine’s efficacy against the severe disease was 85.4 per cent, but it fell to 66.1 per cent when including moderate forms of the disease.

However, unlike the shots from Moderna and Pfizer, the vaccine has won praises for its single dosage and because it does not need to be frozen.

In December, J&J entered into a partnership with Gavi, formerly the Global Alliance for Vaccines and Immunisation based in Geneva, to support the vaccination needs of 190 participating economies through its COVAX Facility.

The expected advance purchase agreement between Gavi and J&J will provide up to 500 million doses to COVAX through 2022, according to J&J.

Data from the Phase 3 ENSEMBLE study showed that the J&J COVID-19 vaccine reduced symptomatic COVID-19 in 67% of participants. Protection was observed from day 14 and was maintained 28 days post-vaccination.

Additionally, the vaccine was 85 per cent effective in preventing severe disease and showed protection against COVID-19 related hospitalization across different variants beginning 28 days after vaccination, the data found.

J&J is working with nine partners across four continents, including Aspen Pharmacare in South Africa, to manufacture and ship its vaccine.

Aspen will support vaccine shipments to the AU and will also contribute to the global availability of the vaccine, according to the announcement.

Adedapo Adesanya is a journalist, polymath, and connoisseur of everything art. When he is not writing, he has his nose buried in one of the many books or articles he has bookmarked or simply listening to good music with a bottle of beer or wine. He supports the greatest club in the world, Manchester United F.C.

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Health

Resident Doctors Suspend Proposed Indefinite Strike

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Resident Doctors

By Adedapo Adesanya

The Nigerian Association of Resident Doctors (NARD) has suspended its planned indefinite strike following the federal government’s reversal of the implementation of the reviewed Professional Allowance Table (PAT) and renewed assurances on outstanding payments.

The decision was announced in a communiqué issued at the end of an emergency National Executive Council (NEC) meeting held virtually on Saturday.

NARD had earlier resolved to embark on a total and indefinite strike over the government’s suspension of the reviewed allowance structure and other unresolved welfare concerns affecting resident doctors nationwide.

However, the association said it reconsidered its position after reviewing the outcomes of high-level engagements with key government officials and health-sector stakeholders.

According to the communiqué signed by NARD President, Dr Mohammad Usman Suleiman; Secretary-General, Dr Shuaibu Ibrahim; and Publicity and Social Secretary, Dr Abdulmajid Yahya Ibrahim, the Federal Government has now reversed its earlier decision on the allowance table.

“The NEC observed that the earlier decision to halt the implementation of the reviewed Professional Allowance Table (PAT) has been reversed, with implementation expected to reflect in the April salary and beyond,” the statement read.

The association also noted the government’s renewed commitment to settling outstanding promotion and salary arrears owed to resident doctors in affected institutions.

In addition, NARD said initial approval had been secured for the 2026 Medical Residency Training Fund (MRTF), with assurances that the disbursement process would be concluded.

“The NEC observed that the Budget Office has indicated its readiness to commence the process for the payment of the outstanding nineteen months’ arrears of the Professional Allowance,” the communiqué added.

Despite the progress, the doctors expressed concern about the continued delay in paying house officers’ salaries and called for urgent action to address the issue.

Following its deliberations, the NEC demanded the sustained implementation of the reviewed allowance structure, the prompt payment of all outstanding arrears, and the expedited disbursement of the residency training fund.

It also called for the immediate commencement of the process to clear the 19-month arrears and the convening of an urgent stakeholders’ meeting to resolve delays affecting house officers’ salaries.

“In light of the above developments, the NEC resolves to suspend the proposed total, indefinite, and comprehensive strike action, with a review of progress to be undertaken at the May Ordinary General Meeting (OGM) in Kano,” the statement said.

NARD expressed appreciation to President Bola Tinubu, Vice President Kashim Shettima, and several ministers, government agencies, and stakeholders for their interventions in resolving the dispute.

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Over 1.5 million Nigerian Children Living With Sickle Cell Disease—Report

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sickle cell disease

By Modupe Gbadeyanka

More than 1.5 million children under the age of 15 are living with sickle cell disease in Nigeria, a new international study published in The Lancet Child & Adolescent Health, one of the world’s leading medical journals, has revealed.

In the report made available to Business Post, it was disclosed that Nigeria carries the highest burden of disease globally, far exceeding other high-burden countries such as the Democratic Republic of the Congo and Ethiopia.

The findings highlight both the scale of the challenge in Nigeria and the opportunity for the country to lead Africa in tackling one of the most preventable causes of childhood illness and death.

The study shows that nearly nine million children across sub-Saharan Africa are living with sickle cell disease in 2023, including around 1.17 million infants and 2.75 million children under five, who face the highest risk of early death without treatment.

Sickle cell disease is an inherited blood disorder present at birth. With early diagnosis and access to simple, low-cost interventions such as newborn screening, penicillin prophylaxis, routine vaccinations, malaria prevention, and hydroxyurea, most complications and deaths can be prevented.

However, in Nigeria, access to these essential services remains limited. Many children are only diagnosed after severe and avoidable complications, while others are never diagnosed at all, contributing to high levels of preventable illness and early childhood deaths.

The researchers emphasise that strengthening Nigeria’s health system response will be critical. This includes expanding newborn screening programmes, improving access to essential medicines, and integrating sickle cell care into primary healthcare services.

They called for urgent and coordinated action across government, health institutions, and development partners, including expanding newborn screening programmes, improving access to essential medicines and vaccines, and embedding sickle cell care within primary healthcare services.

The researchers, led by Professor Davies Adeloye, Professor of Public Health at Teesside University, United Kingdom, and Director of the International Society of Global Health (ISoGH), also called for increased domestic investment, supported by international partnerships, as well as stronger data systems to improve surveillance and guide policy decisions.

They concluded that even modest improvements in early-life screening and treatment in high-burden countries like Nigeria could transform child survival and significantly reduce preventable deaths.

“Nigeria now stands at the centre of the global sickle cell crisis. With over 1.5 million children affected, the scale is enormous, but so is the opportunity to act. We already know what works. Newborn screening and early treatment are effective, affordable, and can be delivered through existing health systems.

“If Nigeria prioritises sickle cell disease within its national health agenda and integrates care into routine maternal and child health services, we could save hundreds of thousands of young lives and significantly reduce avoidable deaths.” Professor Adeloye noted.

It was learned that the study analysed data from 40 studies across 22 African countries to produce the most comprehensive country-level estimates of childhood sickle cell disease to date.

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Health

Helical Secures $10m Funding Package for Expansion

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Helical

By Dipo Olowookere

A $10 million capital has been raised by Helical to support expansion across more top-20 pharma programmes and growth of its deployed science engineering team.

The firm will also use the money to build the compounding evidence layer that improves performance across diseases, as its mission is to make every scientist able to test hypotheses at the speed of inference and to turn in-silico discovery into a reliable engine for R&D throughput.

The funding package was from redalpine, Gradient, BoxGroup, Frst and notable angels, including Aidan Gomez (CEO Cohere), Clement Delangue (CEO HuggingFace) and Mario Goetze (pro soccer player).

Helical has a product known as the virtual AI lab for pharma, an application layer that turns biological foundation models into decision-ready, reproducible in-silico discovery workflows.

The platform has two product surfaces — the Virtual Lab for biologists and translational scientists, and the Model Factory for ML engineers and data scientists — built on the same data, the same models, and the same results.

By putting both sides in the same system, Helical closes the gap between computational predictions and biological decision-making, so teams that traditionally worked in silos can collaborate on the same evidence.

Helical was founded in early 2024. It was created by three school friends who took different paths to the same problem.

Rick Schneider built tech at Amazon and later helped the German enterprise Celonis scale in France and Japan. Maxime Allard led data science teams at IBM before pursuing a PhD focused on reinforcement learning and robotics. Mathieu Klop became a cardiologist and genomics researcher.

When bio foundation models emerged, the trio saw the chance to build the missing application layer that would let pharma teams move from model experimentation to reproducible, production discovery.

“The models alone don’t discover drugs. The system does. Pharma teams need a system that turns foundation models into workflows scientists can run, validate, and defend.

“We built Helical to make in-silico science reproducible at pharma scale, so teams can go from hypothesis to decision in days instead of months,” the co-founder of Helical, Mr Rick Schneider, said.

“We are at a unique point in time where biological foundation models and general language reasoning models are converging.

“We backed Helical because we strongly believe they have what it takes to build the pharma AI orchestration platform that will drive this transition from siloed AI models to integrated virtual AI labs,” the General Partner at redalpine, Mr Daniel Graf, stated.

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