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Sapu Nano Successfully Completes Initial Safety Cohort of Phase 1b SP-03-B101 Trial; Independent Safety Review Committee Recommends Dose Escalation and European Expansion Underway
Following completion of the protocol-defined 28-day dose-limiting toxicity (DLT) evaluation period for the initial three-patient cohort, the SRC concluded that no dose-limiting toxicities were observed and recommended advancing the study to the next planned dose level. Enrollment into the second dose cohort has commenced.
SP-03-B101 is an open-label, multicenter, Bayesian Optimal Interval (BOIN) dose-escalation study evaluating the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of weekly intravenous Sapu003 in patients with advanced mTOR-sensitive solid tumors. The study is registered on ClinicalTrials.gov (Identifier: NCT07369505).
Following successful completion of the initial safety cohort, the Company has initiated expansion of the SP-03-B101 clinical program into Europe, broadening patient access and supporting the global clinical development strategy for Sapu003.
“The independent Safety Review Committee’s recommendation to advance to the next dose level provides important clinical validation of the Sapu003 program,” said Dr. Vuong Trieu, Chief Executive Officer of Sapu Nano. “Combined with the expansion of SP-03-B101 into Europe, these milestones position Sapu003 for accelerated clinical development while broadening access for patients with advanced mTOR-sensitive solid tumors.”
Peer-Reviewed Publication Supports Clinical Development
The clinical milestone follows the Company’s recent peer-reviewed publication describing the scientific foundation of Sapu003 and the Deciparticle™ platform:
Min SH, Forero K, Putnam W, Anderson J, Hoff R, Lopp J, Trieu V, Ho K, Lee C. Intravenous Everolimus Formulation (Sapu003) for Clinical Trials. International Journal of Molecular Sciences. 2026;27(13):5775. doi: 10.3390/ijms27135775.
The publication provides the first comprehensive description of the Deciparticle™ platform and describes a stable intravenous everolimus nanoparticle formulation with a mean particle size below 20 nanometers, identification of mPEG-Chol as the optimal carrier, a scalable cGMP manufacturing process suitable for clinical production, and potent preclinical antitumor activity.
Clinical Trial Information
Study Title: SP-03-B101: A Phase 1b Study of Sapu003 (Intravenous Everolimus) in Patients with Advanced mTOR-Sensitive Solid Tumors
ClinicalTrials.gov Identifier: NCT07369505
About Sapu003
Sapu003 is an investigational intravenous formulation of everolimus developed using Sapu Nano’s proprietary Deciparticle™ nanoparticle platform. Sapu003 is designed to overcome the formulation limitations associated with oral everolimus by enabling intravenous administration with a scalable cGMP manufacturing process. The program is currently being evaluated in the Phase 1b SP-03-B101 clinical trial in patients with advanced mTOR-sensitive solid tumors.
About Sapu Nano’s Deciparticle™
Sapu Nano’s Deciparticle™ is a proprietary nanomedicine platform designed to formulate highly water-insoluble therapeutics into ultra-small nanoparticles for intravenous administration. The platform utilizes amphiphilic polymer architectures intended to improve aqueous compatibility, stability, manufacturability, and translational flexibility across multiple therapeutic classes.
Hashtag: #SapuNano
The issuer is solely responsible for the content of this announcement.
About Sapu Nano
Sapu Nano is a biotechnology company developing next-generation nanomedicine platforms to improve drug delivery, enhance therapeutic index, and unlock new clinical potential for established and novel therapeutics, with a primary focus in oncology. For more information, visit www.sapunano.com.
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FEV collaborates with Microsoft on efficient AI model approach for in car applications built on NVIDIA
The focus is on the use of small language models (SLM) such as Microsoft’s Phi-4-mini-instruct in Microsoft Foundry that is powered by NVIDIA DRIVE AGX accelerated compute. The solution allows vehicle functions such as the dashboard or individual vehicle profiles to be configured by voice command. At the same time, the system acts as robust local backup intelligence for cloud-based large language models (LLMs).
More intelligence, robustness and efficiency in the software-defined vehicle
Embedded small language models increase the functional intelligence level of modern vehicles and improve the responsiveness and availability of AI-powered functions. Since inference takes place directly in the vehicle, central functions remain available even when there is a limited or no internet connection. In addition, embedded SLMs enable a reduction in backend and infrastructure costs, as cloud-based LLMs can be supplemented or partially replaced depending on the use case. This helps OEMs economically scale software-defined vehicle functions.
“Our collaboration with Microsoft and NVIDIA showcases how small, efficient language models can transform in-vehicle experiences, delivering powerful functionality without the overhead of larger systems,” said Thomas Hülshorst, Group Vice President Intelligent Mobility and Software at FEV.
“By combining advanced AI frameworks with domain- and task-specific optimizations, FEV and Microsoft are shaping the future of intelligent, voice-driven interfaces that meet the high standards of automotive deployment,” added Boris Scholl, Vice President of Engineering at Microsoft.
The full press release is available here: https://fev.group/689292
– Picture is available at AP –
Hashtag: #FEV
The issuer is solely responsible for the content of this announcement.
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Thailand’s BOI Approves $688 Million Nestlé Investment for AI-Driven Regional Coffee Hub
The approval highlights Thailand’s accelerating momentum in attracting high-tech, high-value food and beverage manufacturing as global corporations seek resilient, technology-driven supply chains in Southeast Asia.
“This greenfield investment will support growing domestic and regional market demand while linking directly with our domestic supply chain,” said Mr. Narit Therdsteerasukdi, Secretary General of the Thailand Board of Investment. “By using local raw materials, helping our farmers and entrepreneurs, and sharing knowledge, this project will boost the potential of the Thai coffee industry and strengthen Thailand’s position as a key food and beverage hub in the region.”
The new automated facility, located in the Araya Industrial Estate in Samut Prakan province, is scheduled to start operations in the fourth quarter of 2028 with an annual capacity of 170,000 metric tons of NESCAFÉ soluble coffee, coffee mixes, and ready-to-drink beverages. The project is expected to create over 520 jobs for Thai engineers and technical specialists.
By integrating AI-driven systems and robotic automation, the facility aims to maximize operational efficiency and minimize its environmental footprint. This directly supports Thailand’s Bio-Circular-Green (BCG) economic agenda.
Nestlé, the world’s largest food and beverage company, counts Thailand among its longest-serving markets. Its NESCAFÉ brand has led the Thai coffee market for more than 50 years, with more than half the market share.
“Thailand has been an important market for Nestlé for more than 130 years,” said Mr. Nikhil Chand, Chairman and Chief Executive Officer of Nestlé Indochina. “This investment reflects our confidence in the country and our commitment to contributing positively to Thai society, the economy, local communities, and the environment. The new facility will use a wide range of locally sourced ingredients including coffee beans, sugar, and fresh milk, further supporting local agriculture and economic development.”
A key factor in the BOI’s approval is the project’s deep integration into the domestic economy. Nestlé will source USD 130 million (4.3 billion baht) worth of local agricultural inputs and raw materials each year.
In tandem with the manufacturing expansion, Nestlé will drive upstream agricultural development by researching climate-resilient coffee varieties, distributing high-quality saplings, and training local farmers in sustainable, high-yield cultivation practices.
“Nestlé’s choice to invest in coffee production here reflects the confidence global investors place in Thailand. It advances our strategy to become a world-leading food and beverage production base,” Mr. Narit said. “This investment strengthens the entire coffee value chain, from farming and processing to logistics and export. And it builds a stronger, more resource-efficient foundation for Thailand’s food and beverage industry.”
Note: Currency conversions are based on the Bank of Thailand’s average selling rate of approximately 1 USD = 33.3 THB.
Hashtag: #Thailandboardofinvestment #BOI #FDI #Investment
https://www.boi.go.th/en/index/
The issuer is solely responsible for the content of this announcement.
About Thailand Board of Investment (BOI)
Established in 1966, the Office of the Board of Investment (BOI) has continuously played an essential role for over 60 years in promoting value-adding investment for the country, from both foreign and Thai investors, to enhance national competitiveness and drive towards a new era of sustainable and balanced growth.
Investment Services Center — PR Section, The Office of the Board of Investment (BOI)
555 Vibhavadi-Rangsit Road, Chatuchak Bangkok 10900 Tel. +66 (0) 2553 8111, Fax: +66 (0) 2553 8222
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Dusit International expands ASAI Hotels pipeline in Thailand with new lifestyle hotels in Hat Yai and Phuket
Designed for today’s experience-driven travellers, the locally inspired hotel brand will bring its distinctive blend of thoughtful design, meaningful connections, and neighbourhood experiences to two of Southern Thailand’s most dynamic destinations
BANGKOK, THAILAND – Media OutReach Newswire – 9 July 2026 – Dusit International, one of Thailand’s leading hotel and property development companies, is expanding the domestic footprint of its distinctive lifestyle brand, ASAI Hotels, with the signing of hotel management agreements for two new properties in Southern Thailand: ASAI Hat Yai and ASAI Patong Phuket.
Scheduled to open in 2028 and 2029 respectively, the new-build properties reflect Dusit’s strategy to grow ASAI Hotels in destinations where culture, community, dining, and discovery come together to shape memorable stays.
Created for curious travellers seeking authentic local connections, thoughtful design, and quality experiences at accessible rates, ASAI Hotels combines compact, intelligently designed rooms with vibrant communal spaces that encourage guests to eat, work, play, and connect. Each hotel is designed to integrate with its surrounding neighbourhood, working with local businesses, creators, and communities to help guests experience each destination from a fresh perspective.
Since debuting in Thailand with ASAI Bangkok Chinatown in 2020, the brand has expanded to include ASAI Bangkok Sathorn and ASAI Kyoto Shijo in Japan. Its growing pipeline reflects increasing demand for lifestyle-led accommodation that combines convenience and comfort with authentic connections to the surrounding community.
“Today’s travellers are increasingly looking beyond traditional hotel stays. They want places that reflect the character of their destination, provide opportunities for connection, and deliver meaningful experiences without compromising on quality or value,” said Chanin Donavanik, Group CEO, Dusit International. “ASAI Hotels was created with these evolving expectations in mind, and the signing of ASAI Hat Yai and ASAI Patong Phuket demonstrates our confidence in the long-term potential of Thailand’s lifestyle hospitality segment. Both destinations have their own unique energy and strong growth prospects, and we look forward to introducing hotels that connect guests with the communities, culture, and experiences that make each location special.”
Located on Samchai Road in the heart of Hat Yai’s city centre, ASAI Hat Yai will introduce the brand to one of Southern Thailand’s most important commercial and tourism hubs. A key gateway connecting Thailand with Malaysia and the wider region, Hat Yai continues to attract strong domestic and cross-border demand, supported by its transport links, thriving local businesses, popular street food scene, and distinctive Thai-Chinese heritage.
The hotel will comprise 116 thoughtfully designed guestrooms created for different styles of travel – from comfortable spaces for solo travellers and couples to larger rooms with bunk beds designed for families and groups of friends.
Facilities will include an all-day dining restaurant, café and bar, flexible co-working spaces, meeting facilities, and a fitness centre, all designed to create a vibrant neighbourhood hub where guests and locals can connect.
ASAI Patong Phuket, meanwhile, will bring the brand’s locally inspired approach to Phuket, one of Asia’s most visited island destinations and a global tourism hub that continues to attract strong demand from international and domestic travellers.
Located in the heart of Patong, just five minutes from Patong Beach and around one hour by car from Phuket International Airport, the hotel will feature approximately 85 rooms alongside a lively ground-floor café and social space built around ASAI’s signature Eat/Work/Play concept, a rooftop swimming pool, and fitness facilities. Designed to reflect Patong’s dynamic blend of beach culture, local dining, entertainment, and creative energy, the hotel will provide a welcoming base for travellers looking to experience Phuket beyond the traditional resort stay.
The ASAI Hotels brand is set to continue its international expansion in Q3 2026 with the opening of ASAI Gamuda Cove in Malaysia. Located within the 1,530-acre Gamuda Cove township near Kuala Lumpur, the hotel will mark the brand’s debut in Malaysia and introduce ASAI’s locally inspired approach within a setting that combines nature, recreation, entertainment, and community experiences. ASAI is also set to expand into the Philippines with ASAI Oslob Cebu (late 2027) and ASAI Camaya Coast (late 2028).
ASAI Hotels is one of nine distinctive brands that make up Dusit Hotels and Resorts, Dusit International’s global hospitality portfolio, encompassing luxury retreats, wellness resorts, lifestyle hotels, and contemporary city stays. The portfolio currently spans 19 countries and comprises 50 hotels, alongside approximately 237 luxury villas under Elite Havens, the leading provider of luxury villa rentals in Asia. More than 50 Dusit Hotels and Resorts properties are in the pipeline worldwide.*
*Portfolio and pipeline figures as of 1Q 2026.
Hashtag: #Dusit
The issuer is solely responsible for the content of this announcement.
About Dusit International
Established in 1949,
Dusit International or Dusit Thani Public Company Limited (DUSIT) is a leading hospitality group listed on the Stock Exchange of Thailand. Its operations comprise five distinct yet complementary business units: Dusit Hotels and Resorts, Dusit Hospitality Education, Dusit Foods, Real Estate Development, and Hospitality-Related Services.
Dusit International‘s diversified investments in real estate development, hospitality-related services, and the food sector are part of its long-term strategy for sustainable growth, which focuses on three key areas: balance, expansion and diversification.
For more information, please visit
dusit-international.com
About Dusit Hotels and Resorts
Dusit Hotels and Resorts is the hotel arm of Dusit International. With a heartfelt belief and commitment to introducing Thai-inspired gracious hospitality to the world, Dusit Hotels and Resorts offers guests a uniquely special stay in high-style surroundings and a personalised approach to service. The group’s portfolio of hotels, resorts and luxury villas includes close to 300 properties operating under a total of nine brands (Devarana – Dusit Retreats, Dusit Thani, Dusit Suites, Dusit Collection, Dusit Hotels, dusitD2, Dusit Princess, ASAI Hotels, and Elite Havens) across 19 countries worldwide.
For more information, please visit
dusit.com


