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The United Laboratories and Novo Nordisk announce exclusive license agreement for UBT251, a GLP-1/GIP/glucagon triple receptor agonist

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GUANGDONG, CHINA AND BAGSVÆRD, DENMARK – Media OutReach Newswire – 24 March 2025 – The United Laboratories International Holdings Limited (TUL) and Novo Nordisk A/S (Novo Nordisk) today announced that Novo Nordisk and TUL’s wholly-owned subsidiary The United Bio-Technology (Hengqin) Co., Ltd. (United Biotechnology), have entered into an exclusive license agreement for UBT251, a triple agonist of the receptors for GLP-1, GIP, and glucagon in early-stage clinical development for the treatment of obesity, type 2 diabetes, and other diseases.

Under the license agreement, Novo Nordisk will obtain exclusive worldwide rights (excluding Chinese mainland, Hong Kong, Macau, and Taiwan) to develop, manufacture, and commercialize UBT251. United Biotechnology will retain the rights for UBT251 in Chinese mainland, Hong Kong, Macau, and Taiwan. United Biotechnology is eligible to receive an upfront payment of 200 million US dollars and potential milestone payments of up to 1.8 billion dollars from Novo Nordisk, as well as tiered royalties on net sales outside of Chinese mainland, Hong Kong, Macau, and Taiwan.

“Novo Nordisk is dedicated to providing improved treatment options for people living with obesity, type 2 diabetes, and other cardiometabolic diseases. The addition of a candidate targeting glucagon, as well as GLP-1 and GIP, will add important optionality to our clinical pipeline, as we look to develop a broad portfolio of differentiated treatment options that cater to the diverse needs of people living with these highly prevalent diseases,” said Martin Holst Lange, executive vice president for Development at Novo Nordisk. “We look forward to building on United Biotechnology’s scientific work and further exploring the potential best-in-class properties of UBT251 across cardiometabolic disease indications.”

United Biotechnology recently completed a randomized, double-blind, placebo-controlled phase 1b trial in China designed to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple subcutaneous injections of UBT251 in people with overweight or obesity.

A total of 36 patients were enrolled in three different dose groups (1mg, 1mg/3mg, 1mg/3mg/6mg). Each group adopted a dose titration method, with subcutaneous injection once a week for 12 consecutive weeks.

The safety profile of UBT251 was consistent with incretin-based therapies. The most common adverse events were gastrointestinal and the vast majority were mild to moderate in severity. In the highest dose group, the average weight of the people who completed the trial decreased by 15.1% from baseline, while the average weight of people in the placebo group increased by 1.5% from baseline.

“We are pleased to announce our exclusive license agreement with Novo Nordisk for UBT251. As a leading global biopharmaceutical company, Novo Nordisk holds a strong position in the treatment of chronic diseases,” said Mr. Tsoi Hoi Shan, the Chairman of TUL. “TUL is committed to strengthening its presence in the treatment of chronic diseases, including endocrine and metabolic disorders, while actively expanding its footprint in global markets. We believe that Novo Nordisk’s expertise will play a key role in accelerating the global development of UBT251.”

This collaboration represents a pivotal milestone in TUL’s ongoing efforts to establish a global strategic presence and demonstrates its commitment to innovation-driven transformation. TUL will continue to foster scientific innovation, advance high-quality and sustainable development, and accelerate the establishment of a globally competitive framework for manufacturing, R&D, and commercialization.

The closing of this transaction is subject to applicable regulatory clearance and other customary closing conditions.
Hashtag: #TUL

The issuer is solely responsible for the content of this announcement.

About UBT251

UBT251 is a long-acting synthetic peptide triple agonist targeting the receptors for GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide) and glucagon. It has demonstrated potent activity on all three receptors in a preclinical setting.

UBT251 is categorized as a Class 1 innovative drug in China, being developed by United Biotechnology for multiple indications. To date, UBT251 has been approved for clinical trials in China in adult type 2 diabetes, overweight or obesity, metabolic dysfunction-associated fatty liver disease (MAFLD), and chronic kidney disease (CKD), and for clinical trials in the United States in adult type 2 diabetes, overweight or obesity, and CKD.

United Biotechnology recently initiated a phase 2 trial for UBT251 in people with overweight or obesity in China.

About TUL and United Biotechnology

Founded in 1990, TUL (HKEX: 3933) is mainly engaged in the research and development, production and sales of pharmaceuticals, and ranks among the leading integrated pharmaceutical companies in China. TUL currently boasts seven production bases, covering intermediate products, bulk medicine , finished products, veterinary drugs, empty capsule casings, and medical devices, with the sales networks dotted across nearly 80 countries and regions. United Biotechnology, located in the Guangdong-Macao In-Depth Cooperation Zone in Hengqin, serves as the biopharmaceutical R&D headquarter of TUL. United Biotechnology focuses on the development of high-end biopharmaceuticals to treat major chronic diseases. For more information, please visit .

About Novo Nordisk

Novo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat serious chronic diseases, built upon our heritage in diabetes. We do so by pioneering scientific breakthroughs, expanding access to our medicines, and working to prevent and ultimately cure disease. Novo Nordisk employs about 76,300 people in 80 countries and markets its products in around 170 countries. For more information, visit , , , and .

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SIM and the True Worth of Education: Beyond Tuition Fees

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SINGAPORE – Media OutReach Newswire – 7 December 2025 – As Singaporean families plan for higher education, tuition costs often dominate the conversation. However, the more critical consideration lies in understanding the relationship between cost and value. This article provides an in-depth understanding of the financial implications of pursuing studies at local public universities, private institutions such as SIM, and overseas universities, while highlighting SIM’s distinctive proposition that extends beyond competitive pricing.

Local Public Universities: Affordable and Prestigious

Singapore’s autonomous universities remain among the most cost-effective options for Singapore citizens, thanks to the Ministry of Education’s Tuition Grant. For example, undergraduate programs at NUS and NTU cost around S$8,250 per year for Singaporeans, while SMU averages S$11,500 annually. Other institutions such as SUTD, SUSS and SIT fall within similar ranges, typically between S$8,000 and S$13,500 per year. Over a three- to four-year degree, this translates to roughly S$25,000 to $54,000 in tuition fees.

The autonomous universities offer strong reputations and excellent graduate outcomes, but entry to some programme is highly competitive, and program flexibility may be limited compared to private or overseas options.

Overseas Universities: Prestige Comes at a Price

For families considering an overseas education, costs escalate dramatically. Tuition at U.S. private universities averages US$50,000 to US$60,000 per year (about S$70,000 to S$84,000), with living expenses adding another US$10,000 to US$15,000 annually. In the UK, fees range from £10,000 to £38,000 per year (approximately S$17,000 to $65,000), while Canada and Australia typically charge S$14,000 to $28,000 for tuition alone. Factoring in accommodation, travel, and insurance, a four-year overseas degree can easily exceed S$150,000.

While these programs offer prestige and cultural immersion, they also involve significant financial, visa, and lifestyle considerations.

SIM Global Education: International Degrees at Local Cost

SIM offers a compelling alternative for students seeking global credentials without the high cost of studying abroad. Through partnerships with leading universities from the UK, Australia, the U.S., Canada, and Europe, SIM delivers more than 140 programs in Singapore, allowing students to earn internationally recognized degrees, essentially the same degree if you studied overseas, but locally at SIM. Tuition fees vary by program, for example, a University of London BSc ranges from S$26,685 to S$42,835, a University of Birmingham top-up degree costs S$42,000 to S$57,100, and a degree from the University at Buffalo falls between S$41,700 and S$74,600 for Singaporeans.

Beyond competitive pricing, SIM emphasizes value. Degrees are awarded by partner universities and aligned with global academic standards. The institution holds EduTrust Star certification and ISO accreditation, ensuring the best quality assurance. Students benefit from bond-free scholarships and bursaries, as well as Career Connect services that provide internships, mentoring, and employer networking. Graduate outcomes are strong, with nearly 80% of SIM graduates securing employment within six months of graduation.

Why Value Matters as Much as Cost

Choosing a degree isn’t just about tuition fees, it’s about the total investment, which includes living costs, global recognition, and career outcomes. Local autonomous universities such as NUS, NTU, and SMU remain highly attractive for their subsidized fees and strong reputations, making them one of the most cost-effective options for Singaporeans. However, entry is competitive, and program flexibility may be limited.

On the other end of the spectrum, overseas universities offer prestige and cultural immersion but often come with six-figure costs and additional living expenses. This is where SIM provides a strategic middle ground, delivering internationally recognized degrees from leading global universities at local cost. Students gain access to global curricula, industry-ready skills, and career networks without the financial burden of relocating overseas. For families seeking international exposure at sustainable costs, SIM combines affordability with the value of global education

References:

  1. NUS Fees for Undergraduate Programmes – https://www.nus.edu.sg/registrar/docs/info/administrative-policies-procedures/ugtuitioncurrent.pdf
  2. NTU Fees for Undergraduate Programmes – https://www.ntu.edu.sg/docs/default-source/onestop@sac/2025/tuition-fees-ft-ay2025_12mar25.pdf?sfvrsn=b8c5474_1
  3. SMU Fees for Undergraduate Programmes – https://admissions.smu.edu.sg/financial-matters/tuition-fees-grant
  4. SUTD Fees for Undergraduate Programmes – https://www.sutd.edu.sg/admissions/undergraduate/education-expenses/fees/tuition-fees/
  5. SUSS Fees for Undergraduate Programmes – https://www.suss.edu.sg/admissions/financial-matters/tuition-fee-subsidy/full-time-undergraduate
  6. SIT Fees from Undergraduate Programmes – https://www.suss.edu.sg/admissions/financial-matters/tuition-fee-subsidy/full-time-undergraduate
  7. Comparison of Tuition Fees in US, UK, Canada and Australia – https://uninist.com/blog/financial-planning/comparison-of-tuition-fees-guide
  8. How much does college cost in 2025 – https://research.com/universities-colleges/how-much-does-college-cost
  9. Price of attending undergraduate institutions – https://nces.ed.gov/programs/coe/indicator/cua
  10. University of London Bachelor Degree – https://www.sim.edu.sg/degrees-diplomas/programmes/programme-listing?academic=2%7C&programmetype=1%7C3&university=1%7C
  11. University of Brimingham Bachelor Degree – https://www.sim.edu.sg/degrees-diplomas/programmes/programme-listing?academic=2%7C&programmetype=1%7C3&university=10%7C

Hashtag: #SIMGlobalEducation #SIMGE #GlobalEducation #InternationalDegree #CareerReady #FutureSkills

The issuer is solely responsible for the content of this announcement.

About SIM Global Education

SIM Global Education (SIM GE) is a leading private education institution in Singapore and the region. We offer more than 140 academic programmes ranging from diplomas and graduate diploma programmes to bachelor’s and master’s degree programmes with some of the world’s most reputable universities from Australia, Canada, Europe, United Kingdom, and the United States. SIM GE’s cohort is made up of 16,000 full- and part-time students and adult learners, of which approximately 36% are international students hailing from over 50 countries.

SIM GE’s holistic learning approach and culturally diverse learning environment aim to equip students with knowledge, industry skills and employability competencies, as well as a global perspective to succeed as future leaders in a fast-changing, technologically driven world.

For more information on SIM Global Education, visit sim.edu.sg

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A-Level vs Polytechnic: Understanding different pathways offer competitive edge at SIM

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SINGAPORE – Media OutReach Newswire – 6 December 2025 – Singapore’s education system offers two popular tertiary pathways after post-secondary, A-Levels through Junior Colleges and Polytechnic diplomas. Both leading to higher education but differ in focus. A-Levels are academically rigorous and theory-driven, preparing students for university through subject-based learning over two years at junior colleges or three years at Millennia Institute.

Conversely, Polytechnic programmes emphasize applied learning, incorporating projects and industry attachments, and culminate in a diploma after three years. Understanding how these distinct approaches translate into admission considerations at SIM, one of Singapore’s leading private education institutions, is essential.

For students and parents, evaluating these options is critical to determining which pathway offers the greatest advantage in today’s competitive education landscape.

Applying with A-Levels

For students who have completed A-Levels, SIM requires applicants to meet the academic and English language criteria specified for each degree programme. According to SIM’s admissions process, candidates must submit their GCE A-Level certificates and transcripts along with other supporting documents. Entry is subject to programme-specific requirements set by SIM and its universities partner from Australia, Canada, Europe, the United Kingdom, and the United States. This pathway allows applicants to begin their degree studies immediately after junior college, provided they meet the specific entry requirements for their chosen programme.

Applying with a Polytechnic Diploma

Polytechnic graduates may be eligible for advanced standing and credit exemptions when applying to SIM’s degree programmes. The amount of exemption depends on the relevance of the diploma and the chosen degree. For example, IT-related diplomas from local polytechnics can receive up to two years of credit exemptions for certain programmes, such as those offered by the University of Wollongong, provided the applicant meets GPA requirements (typically 2.0 or above). Other diplomas may receive partial exemptions on a case-by-case basis. These exemptions reduce both time and cost, making SIM an attractive option for Polytechnic graduates who want to build on their applied learning experience.

Why It Matters

According to the Ministry of Education (MOE) statistics in 2021, roughly one in three Polytechnic graduates progress to local autonomous universities, compared to about four in five A‑Level and International Baccalaureate graduates. This gap underscores the importance of additional pathways such as SIM, which enable Polytechnic graduates to earn globally recognised degrees and expand their career prospects.

Student Stories: Two Potential Paths to Success at SIM

At SIM, students have the flexibility to shape their academic journey based on their background and career goals. For some, it’s about gaining a head start; for others, it’s about leveraging credit exemptions to fast-track progress. Ashley Ong and Violet Weng exemplify these two pathways, each leading to success in its own way.

Ashley Ong, an A-Level graduate, chose to begin her degree journey with the University at Buffalo Bachelor of Science in Business Administration. She embraced every opportunity SIM offered such as internships, hackathons, and networking events, building practical skills and global perspectives that prepared her for a competitive business world.

Meanwhile, Violet Weng, a Singapore Polytechnic graduate, opted for a different approach. While pursuing her RMIT Bachelor of Business (Economics and Finance), Violet leveraged SIM’s credit exemptions to shorten her study duration and reduce costs, all while working full-time. This flexibility allowed her to balance work and study, accelerate graduation, and advance her career without compromise.

Both stories highlight SIM’s commitment to offering customized pathways for students whether you’re starting fresh or building on prior learning.

Conclusion

Whether you come from an academic route like A-Levels or an applied learning path through Polytechnic, the journey to a degree can look very different. A-Level graduates often enjoy a head start with direct entry, while Polytechnic graduates benefit from credit exemptions that recognize their practical skills. Both pathways reflect Singapore’s evolving education landscape where flexibility and global opportunities matter more than ever.

References:

  1. MOE Post-Secondary – https://www.moe.gov.sg/post-secondary/
  2. SIM Application Process – https://www.sim.edu.sg/degrees-diplomas/admissions/application-process
  3. SIM-UOW Credit Exemption Table – https://www.sim.edu.sg/getmedia/9c0ad90d-5910-4d47-b044-f815188a4b16/sim002856.pdf
  4. MOE Education Statistics Digest – https://www.moe.gov.sg/about-us/publications/education-statistics-digest
  5. Polytechnic graduates progression and subsidies for PEIs – https://www.moe.gov.sg/news/parliamentary-replies/20210510-polytechnic-graduates-progression-and-subsidies-for-peis
  6. askST: How many uni places are there for Singaporeans? Is there a quota for poly grads? – https://www.straitstimes.com/singapore/how-many-uni-places-for-locals-any-quota-for-poly-grads
  7. How 6 internships, 4 hackathons, and CCAs paved the way for Ashley – https://www.sim.edu.sg/articles-inspirations/how-6-internships-4-hackathons-and-ccas-paved-the-way-for-ashley
  8. How this graduate pivoted her career by pursuing a degree while working full time – https://www.sim.edu.sg/articles-inspirations/how-this-graduate-pivoted-her-career-by-pursuing-a-degree-while-working-full-time

Hashtag: #SIMGlobalEducation #SIMGE

The issuer is solely responsible for the content of this announcement.

About SIM Global Education

SIM Global Education (SIM GE) is a leading private education institution in Singapore and the region. We offer more than 140 academic programmes ranging from diplomas and graduate diploma programmes to bachelor’s and master’s degree programmes with some of the world’s most reputable universities from Australia, Canada, Europe, United Kingdom, and the United States. SIM GE’s cohort is made up of 16,000 full- and part-time students and adult learners, of which approximately 36% are international students hailing from over 50 countries.

SIM GE’s holistic learning approach and culturally diverse learning environment aim to equip students with knowledge, industry skills and employability competencies, as well as a global perspective to succeed as future leaders in a fast-changing, technologically driven world.

For more information on SIM Global Education, visit sim.edu.sg

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K. Wah Group Donates Additional HK$12.07 Million for Tai Po Recovery

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Chairman Mr. Francis Lui Urges Public to Turn Compassion into Action and Vote 7 December

HONG KONG SAR – Wechat: 嘉华集团 K. Wah Group

The issuer is solely responsible for the content of this announcement.

About K. Wah Group

K. Wah Group was founded in 1955 by Dr. Lui Che Woo and has since grown into a diversified multinational corporation. Its core businesses span property development and investment, integrated resort and entertainment, hospitality, and construction materials.

The Group has a strong presence in Mainland China, Hong Kong, Macau, Southeast Asia, and key international markets. Its major subsidiaries include two Hong Kong-listed flagships: K. Wah International Holdings Limited (HKEX: 00173), focused on premium property development and investment; and Galaxy Entertainment Group Limited (HKEX: 00027), a constituent of the Hang Seng Index and a leading gaming and entertainment operator in Macau. Other key members of the Group include Stanford Hotels International and K. Wah Construction Materials Limited. Today, K. Wah Group comprises over 200 subsidiaries worldwide.

Website:

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