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Li Ka Shing Foundation and Temasek Trust Jointly Commit S$12 Million to Acquire Systems and Advance Clinical Trial for Innovative Histotripsy Cancer Therapy in Singapore

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  • Li Ka Shing Foundation (LKSF) and Temasek Trust (TT) are purchasing and donating two Histotripsy Systems to the National Cancer Centre Singapore (NCCS) and the National University Cancer Institute, Singapore (NCIS) in Singapore to perform clinical trials to study novel ultrasound therapy for liver, kidney and pancreatic cancers.
  • The funding from LKSF and TT will be disbursed through a Donor-Advised Fund managed by TT Foundation Advisors (TTFA), which catalyses additional capital from other donors to support cancer research.

SINGAPORE – Media OutReach Newswire – 04 April 2025 – The Li Ka Shing Foundation (LKSF) and Temasek Trust (TT) have committed S$12 million to bring innovative non-invasive ultrasound-based histotripsy tumour clinical trials to Singapore.

The National Cancer Centre Singapore (NCCS) and the National University Cancer Institute, Singapore (NCIS) will each receive one Histotripsy System – the first of such to be available in Southeast Asia. The funding from LKSF and TT will also support a clinical trial in Singapore for patients with liver, kidney, and pancreatic cancers, advancing regional cancer research and innovation.

Mr. Dickson Lim, Head, TTFA, said, “We at TTFA are delighted to have the Li Ka Shing Foundation and Temasek Trust come together to catalyse this important initiative, to study this innovative non-invasive ultrasound-based cancer therapy in Southeast Asia. We are privileged to work alongside NCCS and NCIS to support clinical research and trials to use this novel modality that targets important cancers. Over time, we aim to attract additional philanthropic capital from other donors to sustainably support the next phase of cancer research.”

Rising Regional Cancer Burden and the Need for Innovative Treatment

Liver, kidney, and pancreatic cancers are on the rise across Asia, with Southeast Asia experiencing the fastest-growing incidence and mortality rates. Factors such as aging populations, changing lifestyles, and environmental exposure contribute to the regional cancer burden. In Singapore, liver cancer is the third most common cause of cancer death for men, with liver and pancreatic cancers among the top 10 causes of cancer mortality. These cancers often do not show symptoms until the later stages, making early detection and effective treatment difficult.

Histotripsy: An Innovative Technology

Developed by US medical company, HistoSonics, the HistoSonics Histotripsy System generates microbubbles that rapidly expand and collapse, producing shock waves that break down tumours at the cellular level. This approach does not require surgery, and can non-invasively destroy tumours, including those that cannot be surgically removed.

Unlike surgery, radiotherapy, or traditional ablation, histotripsy requires no incisions or radiation, offering a painless, scarless, and bloodless treatment.

Clinical Trial on Histotripsy Therapy and Research in Asia

The application for the clinical trial using the HistoSonics Histotripsy System is being prepared. Professor Brian Goh Kim Poh, Head of Hepatopancreatobiliary and Transplant Surgery, NCCS and Singapore General Hospital, and principal investigator of the trial, will work alongside a team of oncologists, interventional radiologists and researchers from both NCCS and NCIS.

Professor Goh said, “We are excited to have the opportunity to embark on clinical trials for liver, kidney and pancreatic cancers which are prevalent in Southeast Asia. We plan to initiate trials for liver cancers first. While surgery and local ablative therapies are the main treatment modalities for liver cancers today, not all patients are suited to undergo these invasive treatments due to various factors such as patient fitness, tumour location or underlying liver disease. For these patients, innovations such as histotripsy offer an alternative option with potential advantages as it is non-invasive. We are extremely grateful to the Li Ka Shing Foundation and Temasek Trust for their generosity and strong support towards advancing cancer research by enabling us to study this novel technology.”

Associate Professor Glenn Kunnath Bonney, Senior Consultant, Division of Surgical Oncology, NCIS, said: “We are currently preparing for the clinical trial of histotripsy as a potential treatment approach for patients with liver and other complex cancers. I have just returned from an international meeting where I was shown the promising results from early clinical trials. This initiative reflects our ongoing commitment to expanding evidence-based options through rigorous research, with the goal of improving patient outcomes over time. We are grateful to the Li Ka Shing Foundation and Temasek Trust for their support, and look forward to working with our partners to build the necessary foundation for careful clinical studies.”

The clinical trial is slated to commence later this year, with a targeted enrolment of 40 patients who meet the trial criteria and are reviewed by a multi-disciplinary team.

Ensuring Sustainable Impact through Strategic Philanthropy

To drive long-term impact in the region, the funding from LKSF and TT will be disbursed through a Donor-Advised Fund (DAF) managed by TTFA, the philanthropy advisory services arm of TT. Through the DAF, TTFA aims to attract additional capital from other donors over time to sustainably support the next phase of cancer research.

Hashtag: #LiKaShingFoundation #TemasekTrust

The issuer is solely responsible for the content of this announcement.

About Li Ka Shing Foundation

Li Ka Shing Foundation believes in philanthropy with societal impact. Since 1980, we have been helping to reform education and further medical research. To date, Mr Li Ka-shing has invested over HK$30 billion in projects covering education, medical services, charity and anti-poverty programmes, with about 80% of the projects in Mainland China and Hong Kong.

About Temasek Trust

Temasek Trust was established by Temasek Holdings and is a steward of philanthropic assets. It aims to catalyse positive impact by protecting the planet, uplifting communities, connecting people, and advancing capabilities. By forging new pathways for philanthropy and impact investing with like-minded partners, Temasek Trust seeks to promote catalytic philanthropy as a force for good. For more information, visit . Follow us on

About National University Cancer Institute, Singapore (NCIS)

The National University Cancer Institute, Singapore (NCIS) is an academic, national specialist centre for cancer under the National University Health System (NUHS), and is the only public cancer centre in Singapore that treats both paediatric and adult cancers in one facility.

As one of two national cancer centres in Singapore, NCIS (pronounced as “n-sis”) offers a broad spectrum of cancer care and management from screening, diagnosis and treatment to rehabilitation and survivorship, as well as palliative and long-term care. NCIS’ strength lies in the multidisciplinary approach taken by our clinician scientists and clinician-investigators to develop a comprehensive and personalised plan for each cancer patient.

NCIS provides the full suite of specialised oncology and haematology services at the NUH Medical Centre at Kent Ridge, Singapore, including those by the NCIS Chemotherapy Centre, NCIS Radiotherapy Centre and NCIS Cellular Therapy Centre.

NCIS also offers cancer services at other hospitals in Singapore:
* NCIS Cancer & Blood Clinic @ Ng Teng Fong General Hospital
* NCIS Radiotherapy Centre @ Tan Tock Seng Hospital
* NCIS Radiotherapy Clinic @ Khoo Teck Puat Hospital

To bring cancer care even closer to our patients, our NCIS on the Go programme delivers a range of cancer services at clinics within the community for their convenience. For more information, please visit .

About HistoSonics

HistoSonics is a privately held medical device company developing non-invasive platforms and proprietary sonic beam therapy utilizing the science of histotripsy, a novel mechanism of action that uses focused ultrasound to mechanically destroy and liquify unwanted tissue and tumours. The company is currently focused on commercialising their HistoSonics Histotripsy System in the US and select global markets for liver treatment while expanding histotripsy applications into other organs like kidney, pancreas, prostate, brain, and others. HistoSonics has offices in Ann Arbor, Michigan, and Minneapolis, Minnesota.

For more information on the HistoSonics Histotripsy System, please visit: . For patient related information, please visit: .

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Can Gio Awakens as Ho Chi Minh City’s Next Growth Frontier

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After decades of quiet, Can Gio is awakening on Vietnam’s southern coast, as fresh investment and grand designs breathe new life into the once-remote district of Saigon.

HO CHI MINH CITY, VIETNAM – Media OutReach Newswire – 27 December 2024 – Six months after the groundbreaking of a 2,870-hectare coastal urban project backed by Vingroup, Vietnam’s largest private conglomerate, Can Gio, once seen as a forgotten corner of Ho Chi Minh City, is now emerging as a new growth engine for Vietnam’s southern metropolis.

Vinhomes Green Paradise: A Hidden Gem Poised to Shine in Vietnam’s Real Estate Market.

Breaking Isolation

For years, Can Gio was often left out of the city’s rapid development. Surrounded by dense forests and accessible mainly by ferry, it remained a world apart. Now, that is beginning to change.

Six months ago, the large-scale land reclamation project officially started construction. Locals call it a “game changer” that awakened a land long left behind. Along the coast that once lay quiet, a vast construction site has emerged, with heavy machinery working day and night. “I was very surprised by the speed,” said Prof. Pham Van Song, president of the Mien Dong University of Technology, noting that hundreds of hectares have already been filled and stabilized within months.

The project, developed by Vingroup through its real estate arm Vinhomes, represents one of the group’s most ambitious coastal developments, part of a long-term vision to extend Ho Chi Minh City’s urban footprint toward the sea. With billions of U.S. dollars in investment, it combines housing, tourism, and modern infrastructure within a single master plan that anchors Can Gio’s transformation.

Complementing this project, a series of major infrastructure works are also reshaping the district. By the end of 2025, the Phu My Hung–Can Gio high-speed railway, designed to reach 350 kilometers per hour, is expected to begin construction, linking the area to the city’s southern urban core. In 2026, the long-awaited Can Gio Bridge will break ground, cutting the journey to the city center to around 45 to 60 minutes.

At the same time, the Rung Sac interchange, with an investment of 3,000 billion VND (about 120 million U.S. dollars), will connect Can Gio directly with the Ben Luc–Long Thanh Expressway. Expected to be completed in 2028, it will link Can Gio with both the Southwest and Southeast regions, including Long Thanh International Airport.

In addition, a sea-crossing expressway between Can Gio and Vung Tau, 50 meters wide and proposed by Vingroup, would stretch across the sea for more than 10 kilometers. The plan envisions a wide eight-lane road that could reduce travel between Can Gio and Vung Tau to under 15 minutes, creating a strategic connection between the two coastal economies.

These efforts fit within a broader regional plan that combines road, rail, water, and sea transport. Another key project is the Can Gio International Transshipment Port, covering 571 hectares with an investment of 50,000 billion VND. The port is designed to become a new symbol of Vietnam’s maritime economy, with its first phase scheduled to begin operations in 2027 and full completion before 2045.

“A Single Project Ignites the South”

According to Prof. Pham Van Song, the rise of Can Gio is a natural development, especially with the involvement of Vingroup through its Vinhomes Green Paradise project. He believes that Can Gio is moving from an ecological area on the fringe of development to a new center of growth. “All modes of transportation will be available in Can Gio,” he said. “The district’s GRDP will grow rapidly in line with ongoing construction and investment. Both the number of residents and visitors will surge. Local people will be the first to directly benefit from these projects, and their lives will become increasingly prosperous.”

The changes are already drawing attention from investors. Dinh Minh Tuan, southern regional director of Batdongsan.com.vn, said the number of searches related to Can Gio has tripled since the beginning of the year. After the Vinhomes Green Paradise project broke ground, property interest in the district doubled again. “Just one single project has heated up the entire southern market,” he said.

Experts say this follows a familiar pattern. In the 1990s, Nguyen Van Linh Boulevard helped turn southern Ho Chi Minh City into a thriving area and drew nearly two million residents. In the 2010s, the completion of the Thu Thiem Tunnel and Bridge attracted more than one million people to the city’s east. “Investors who followed the infrastructure development wave then saw huge gains,” Tuan noted. “Can Gio now stands at a similar starting point, but with a stronger push.”

With a population of about 80,000, Can Gio has long faced a single challenge: lack of connectivity. But, “with the series of large-scale investments now under way, Can Gio is expected to grow faster than many of the city’s earlier new urban areas,” said Tuan.
Hashtag: #Vinhomes

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Z.ai Open-Sources GLM-4.7, a New Generation Large Language Model Built for Real Development Workflows

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SINGAPORE – Media OutReach Newswire – 26 December 2025 – Z.ai has released GLM-4.7, the latest version of its open-source large language model, ahead of Christmas, as the company steps up efforts to position its models for real-world software development and production use.

The new model is designed around practical engineering workflows, with a focus on long-running task execution, stable tool calling, and multi-step reasoning, capabilities that have become increasingly important as developers deploy large language models in complex, agent-based systems.

Compared with its predecessor, GLM-4.6, GLM-4.7 shows notable gains in code generation, complex reasoning, and agent execution. According to Z.ai, the model delivers more consistent and controllable performance over extended tasks, while producing cleaner and more concise language output, addressing a common weakness in many open-source models.

To evaluate performance in realistic settings, Z.ai tested GLM-4.7 on 100 practical programming tasks in production-like environments such as Claude Code, spanning front-end, back-end, and command-execution scenarios. The company said GLM-4.7 achieved higher task completion rates and greater stability than GLM-4.6, and has since been adopted as the default model for its GLM Coding Plan.

Benchmark results also place GLM-4.7 among the strongest open-source models currently available. It scored 67.5 on BrowseComp and 87.4 on τ²-Bench, the latter marking a new high for open-source systems. In coding-focused evaluations, including SWE-bench Verified and LiveCodeBench v6, its overall performance approaches that of Claude Sonnet 4.5. In Code Arena’s large-scale blind evaluation, which aggregates votes from more than one million comparisons, GLM-4.7 ranked first among open-source models.

The model is available through the BigModel.cn API and has been integrated into Z.ai’s full-stack development platform, according to the company. As open-source models take on a more prominent role in the global technology ecosystem, Z.ai’s progress offers a clear indication of how such systems may continue to evolve, and what they might enable next.

Default Model for Coding Plan: https://z.ai/subscribe
Try it now: https://chat.z.ai/
Weights: https://huggingface.co/zai-org/GLM-4.7
Technical blog: https://z.ai/blog/glm-4.7

Hashtag: #ZAI

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NIA Joins Forces with TAT to Reignite ‘Amazing Thailand’ Through Innovation Power, Transforming Thai Tourism and Leveraging Creativity and Culture to Drive a New Tourism Economy

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BANGKOK, THAILAND – Media OutReach Newswire – 26 December 2025 – Tourism remains one of the most important engines driving Thailand’s economy. Beyond generating revenue, it plays a vital role in job creation, nation branding, and even influencing investment decisions. However, fostering sustainable growth in the tourism sector is far from straightforward. The industry continues to face multiple challenges, including convenience and accessibility, intensifying competition among destinations worldwide, and changing traveller behaviours — all of which directly affect tourists’ travel decisions.

NIA Joins Forces with TAT to Reignite ‘Amazing Thailand’

Towards the end of this year, Thailand is preparing to reignite global attention with a renewed wave of ‘Amazing Thailand.’ The government and private sector are rolling out a comprehensive set of tourism-stimulus measures that address both economic impact and national image. One of the most talked-about highlights is the appointment of Lalisa ‘Lisa’ Manobal as the new brand ambassador — not only a global-level artist, but also a powerful representation of Thailand’s contemporary image on the world stage.

Another key highlight to watch closely is the launch of the ‘Amazing Thailand Innovation Gadget’ platform, developed through a collaboration between the National Innovation Agency (Public Organisation), or NIA, and the Tourism Authority of Thailand (TAT). This initiative aims to elevate Thailand’s tourism industry into the era of Smart Tourism in a tangible and comprehensive way.

The platform is designed to function as Thailand’s first-ever tourism innovation repository, bringing together tourism-related technologies and solutions in one centralised space. These range from route-planning technologies, accommodation booking systems, and tourist-data management, to experience-creation tools that personalise journeys and enhance engagement. More than a simple innovation directory, the platform represents a turning point — a mechanism that connects entrepreneurs, developers, and creative talents to co-create new ‘Amazing’ experiences, spanning the entire traveller journey from trip planning to the final moment of travel for visitors worldwide.

Learning from Global Leaders Where Tourism Meets Technology

The world has entered an era where tourism is no longer driven solely by beautiful destinations and cultural heritage. Instead, competitiveness increasingly depends on experiences and technology. As a result, many countries are rapidly upgrading their tourism sectors to become smarter, more emotionally engaging, and better aligned with the expectations of modern travellers.

Japan, for example, stands as a model of cultural-innovation integration, leveraging anime, music, cuisine, and fashion as globally recognisable soft power. Recently, the Japanese government has rebooted efforts to fuse cultural roots with advanced technology through initiatives such as Virtual Remix Japan, which enables global audiences to participate in art exhibitions, festivals, and anime worlds in real time via VR and AR. This exemplifies a seamless blend of past and future.

Meanwhile, South Korea has aggressively combined technology and tourism to enhance attractiveness and vibrancy. The country actively promotes start-ups offering cloud-based hotel-management platforms, real-time translation technologies, blockchain services for international tourists, and platforms linking tourism with overseas education. South Korea has also built a tourism ecosystem that integrates smart cities, digital technology, and contemporary culture, using K-pop artists as a major driving force.

In Barcelona, Spain, one of Europe’s leading smart cities, tourism has been elevated through intelligent urban and visitor-experience management. From smart traffic systems and energy-saving public bike services to big-data-driven analysis of tourist behaviour, visitors can plan accommodation, restaurants, and travel routes through a single integrated application. This approach creates a balanced coexistence between tourism and urban life. Together, these examples demonstrate that technology is no longer merely a supporting tool, but the core differentiator in the modern tourism economy.

Amazing Thailand Innovation Gadget: Elevating Thai Tourism Through a Fully Integrated Innovation Ecosystem

NIA and TAT have officially announced a landmark collaboration with the launch of the ‘Amazing Thailand Innovation Gadget’ platform, which serves as Thailand’s first tourism innovation repository. The initiative aims to propel Thai tourism fully into the Smart Tourism era.

The platform aggregates tourism-related technologies and innovative solutions from start-ups and entrepreneurs nationwide, enabling real-world deployment across the entire Thai tourism value chain. Its objective is to build a strong tourism-innovation ecosystem through integrated collaboration across all sectors, while enhancing entrepreneurs’ capacity to apply innovation and technology suited to the specific contexts of different destinations.

This approach is designed to create premium tourism experiences for both domestic and international travellers, delivering sustainable economic and social benefits for Thailand. Importantly, the country will gain a continuously expandable tourism-innovation repository, strengthening long-term competitiveness in the global tourism market.

From Creative Power and Culture to Driving Thailand’s Tourism Economy

Dr. Krithpaka Boonfueng, Executive Director of the National Innovation Agency, stated that the innovations featured on the platform will primarily be Travel Tech-related technologies. The platform is open to start-ups, entrepreneurs, developers, and business partners with the interest and capability to co-create elevated tourism experiences while advancing Thailand’s Smart Tourism ecosystem.

Currently, NIA supports and has incubated more than 80 high-potential tourism-technology start-ups and entrepreneurs, spanning areas such as community-based tourism (Local Alike), hospitality solutions (Ascend Travel), urban mobility (MuvMi), social impact marketplaces (SocialGiver), and backend customer-journey management systems (Appointment Anywhere). These solutions enable entrepreneurs and developers to access tools tailored to their specific contexts.

NIA believes that all stakeholders play a vital role in elevating Thailand’s tourism industry by integrating technology with creativity, culture, and local identity. This integration goes beyond artists, cuisine, or traditional culture, extending into tangible, scalable innovations that create new economic value for local communities.

Thai – Tech – Tourism: A Major Integrated Leap Forward

Dr Krithpaka further noted that tourism is one of the core engines of the global economy, particularly following recovery from the COVID-19 pandemic. According to data from the World Travel & Tourism Council (WTTC), in 2024 the global travel and tourism sector contributed USD 10.9 trillion, or 10% of global GDP, and supported 357 million jobs worldwide.

The United Nations World Tourism Organization (UN Tourism) has emphasised that innovation is a critical driver of economic growth, enabling new business models, attracting investment, and differentiating destinations through unique tourism formats.

Another crucial factor not to be overlooked is the global TravelTech investment ecosystem, which remains robust. In the post-pandemic era, major tourism companies have increased technology investment by an average of 14% in 2024, reflecting strong confidence in technology as a competitive advantage.

Key areas of investment focus include Smarter Retailing and Personalisation, which deliver highly tailored customer experiences; GenAI and Autonomous Agents, next-generation AI capable of analysing, planning, and executing tasks independently — such as automated travel recommendations, trip planning, and booking management; and Sustainability, with growing investment in start-ups that reduce carbon emissions through diverse solutions.

These global trends align closely with the capabilities and diversity of Thai start-ups, positioning Thailand to connect seamlessly with international movements and deliver truly tangible ‘Amazing’ experiences.

NIA stands ready to connect knowledge, technology, and innovation capital across public agencies, private enterprises, and Thai start-ups to drive concrete outcomes in the tourism-innovation ecosystem. This effort extends beyond enhancing tourism businesses; it represents the creation of a future-oriented industry that fuses creativity and culture with technological power.

Through this integrated approach, Thailand aims to elevate economic value, cultural richness, and sustainability — and to advance decisively towards becoming a Global Innovation Tourism Hub in a meaningful and lasting way.
Hashtag: #NIA #NationalInnovationAgency

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